[1]蒋冠,黄小凤,庞雁宇,等.夫西地酸联合糠酸莫米松治疗慢性家族性良性天疱疮22例临床观察[J].中国皮肤性病学杂志,2017,(11):1281-1284.[doi:10.13735/j.cjdv.1001-7089.201701001]
 JIANG Guan,HUANG Xiao-feng,PANG Yan-yu,et al.Clinical Observation of Fusidic Acid Cream Therapy Combined with Mometasone Furoate Cream for Hailey-Hailey Disease[J].The Chinese Journal of Dermatovenereology,2017,(11):1281-1284.[doi:10.13735/j.cjdv.1001-7089.201701001]
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夫西地酸联合糠酸莫米松治疗慢性家族性良性天疱疮22例临床观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2017年11期
页码:
1281-1284
栏目:
药物与临床
出版日期:
2017-11-01

文章信息/Info

Title:
Clinical Observation of Fusidic Acid Cream Therapy Combined with Mometasone Furoate Cream for Hailey-Hailey Disease
作者:
蒋冠1黄小凤2庞雁宇1刘子重3
1.徐州医科大学附属医院皮肤性病科,江苏 徐州221002; 2.武汉大学人民医院皮肤性病科,湖北 武汉430072; 3.镇江市第四人民医院皮肤性病科,江苏 镇江212001.
Author(s):
JIANG Guan1 HUANG Xiao-feng2 PANG Yan-yu1 LIU Zi-zhong3
1.Department of Dermatology and Venereology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu, China; 2.Department of Dermatology and Venereology, Renmin Hospital of Wuhan University, Wuhan 430072, Hubei, China; 3.Department of Der
关键词:
夫西地酸 糠酸莫米松 天疱疮慢性家族性良性
Keywords:
Fusidic acid cream Mometasone furoate cream Chronic familial benign pemphigus
分类号:
R 758.5
DOI:
10.13735/j.cjdv.1001-7089.201701001
文献标志码:
A
摘要:
目的 观察夫西地酸乳膏联合糠酸莫米松乳膏治疗慢性家族性良性天疱疮的疗性及安全性。方法 将入选的62例慢性家族性良性天疱疮患者通过随机数字表法分为3组:A组(22例)予夫西地酸乳膏联合糠酸莫米松乳膏外用,B组(20例)予糠酸莫米松乳膏外用; C组(20例)予夫西地酸乳膏外用,均2次/d,连用2周。结果 治疗2周后,A组、B组和C组有效率为95.45%,65.00%和60.00%,秩和检验3组相比差异均有统计学意义(χ2=10.703,P=0.005),A组疗效优于B组和C组(A>B,Z=-2.69,P=0.007; A>C,Z=-2.934,P=0.003)。62例患者均完成实验,无明显不良反应。结论 夫西地酸联合糠酸莫米松治疗慢性家族性良性天疱疮疗效显著,安全可靠。
Abstract:
Objective To evaluate the efficacy and the safety of fusidic acid cream combined with mometasone furoate cream in the treatment of Hailey-Hailey disease.Methods Sixty-two patients with Hailey-Hailey disease were divided into three groups randomly according to random number table.Twenty-two patients in A group were treated with fusidic acid cream and mometasone furoate cream twice daily for two weeks, while 20 patients in B group topically applying mometasone furoate cream twice daily for two weeks and 20 patients in C group topically applying fusidic acid cream twice daily for two weeks.Results The effective rate in the A group, B group, C group were separately 95.45%,65.00%,60.00% at the end of treament.Compared to the three groups, the differences were statistically significant by rank-sum test(χ2=10.703,P=0.005).The curative effect in the A group was significantly higher than that in the B group or C group(A>B,Z=-2.69,P=0.007; A>C,Z=-2.934,P=0.003).Conclusion The fusidic acid cream combined with mometasone furoate cream is a safe and effective therapy for Hailey-Hailey disease.

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备注/Memo

备注/Memo:
[通讯作者] 蒋冠,E-mail: dr.guanjiang@gmail.com
更新日期/Last Update: 2017-11-01