[1]李珺莹,李红,吉彬,等.清热解毒汤治疗血热型寻常性银屑病的疗效观察及对血清TNF-α的影响[J].中国皮肤性病学杂志,2017,(05):554-556.[doi:10.13735/j.cjdv.1001-7089.201608018]
 LI Jun-ying,LI Hong,JI Bin,et al.The Efficacy of QingReJieDu Decoction in the Treatment of Psoriasis Vulgaris with the Pattern of BloodHeat and the Influence on Level of TNFα in the Serum[J].The Chinese Journal of Dermatovenereology,2017,(05):554-556.[doi:10.13735/j.cjdv.1001-7089.201608018]
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清热解毒汤治疗血热型寻常性银屑病的疗效观察及对血清TNF-α的影响
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2017年05期
页码:
554-556
栏目:
中医中药
出版日期:
2017-05-01

文章信息/Info

Title:
The Efficacy of QingReJieDu Decoction in the Treatment of Psoriasis Vulgaris with the Pattern of BloodHeat and the Influence on Level of TNFα in the Serum
作者:
李珺莹李红吉彬张峻岭
天津市中医药研究院附属医院(长征医院)皮肤科,天津 300121
Author(s):
LI Jun-ying LI Hong JI Bin ZHANG Jun-ling
Department of Dermatology, Changzheng Hospital, Tianjin Academy of Traditional Chinese medicine Affiliated Hospital, Tianjin300121, China
关键词:
清热解毒汤寻常性银屑病血热型TNF-α
Keywords:
QingReJieDu decoction Psoriasis vulgaris Pattern of BloodHeat TNF-α
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201608018
文献标志码:
B
摘要:
目的 观察清热解毒汤治疗血热型寻常性银屑病的临床疗效,探讨其对血清TNFα的影响情况。〖HTH〗方法 将入选的60例患者随机分成两组,全部患者予外用维A酸哈西奈德乳膏,2次/d;治疗组(30例)同时予口服清热解毒汤,2次/d,所有患者的疗程均为4周。采用PASI评分评价治疗前后的临床疗效,酶联免疫吸附试验(ELISA)法检测治疗前后血清TNFα水平。〖HTH〗结果 治疗结束后,治疗组有效率(800%)明显高于对照组有效率(30%),治疗组PASI评分和血清TNFα水平均较其治疗前明显降低,且治疗组PASI评分(380±147)明显低于对照组PASI评分(962±197),以上差异均有统计学意义(P均<005)。〖HTH〗结论 清热解毒汤治疗血热型寻常性银屑病疗效显著,可能通过降低患者血清TNFα水平发挥治疗作用。
Abstract:
Objective〖WTBZ〗〓To observe the clinical efficacy of QingReJieDu decoction in the treatment of psoriasis vulgaris patients with the pattern of bloodheat and the influence on level of TNFα in the serum〖WTHZ〗Methods〖WTBZ〗〓All selected 60 patients were randomly divided into two groups All patients were given topical tretinoin/halcinonide cream (twice a day)Treatment group(30 cases) was treated with QingReJieDu decoction by oral administration (twice a day) at the same time All groups were treated for 4 weeks The clinical efficacy was evaluated by PASI score before and after treatment Meanwhile, levels of TNFα in serum were detected by enzyme linked immunosorbent assay ELISA 〖WTHZ〗Results〖WTBZ〗〓After treatment, the effective rate of the treatment group(800%)was significantly higher than that of the control group(30%); the PASI score and the level of TNFα in the serum of treatment group were significantly decreased; and the PASI score of the treatment group(380±147)was significantly lower than that of the control group(962±197) All of these differences were statistically significant compared with control group(P<005)〖WTHZ〗Conclusion〖WTBZ〗〓QingReJieDu decoction in the treatment of psoriasis vulgaris patients with the pattern of bloodheat is effective, possibly by reducing expression level of TNFα in the serum.

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更新日期/Last Update: 2017-05-10