[1]施健,缪旭,花志祥,等.角化棘皮瘤43例临床及病理分析[J].中国皮肤性病学杂志,2017,(04):400-402.[doi:10.13735/j.cjdv.1001-7089.201610008]
 SHI Jian,MIAO Xu,HUA Zhi-xiang,et al.Clinical and Pathological Analysis with 43 Cases of Keratoacanthoma[J].The Chinese Journal of Dermatovenereology,2017,(04):400-402.[doi:10.13735/j.cjdv.1001-7089.201610008]
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角化棘皮瘤43例临床及病理分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2017年04期
页码:
400-402
栏目:
临床经验
出版日期:
2017-04-01

文章信息/Info

Title:
Clinical and Pathological Analysis with 43 Cases of Keratoacanthoma
作者:
施健缪旭花志祥林桦
南通大学第二附属医院皮肤科,江苏 南通 226001
Author(s):
SHI JianMIAO XuHUA Zhi-xiangLIN Hua
Department of Dermatology,the Second Affiliated Hospital of Nantong University,Nantong 226001,China
关键词:
角化棘皮瘤 临床表现 病理诊断
Keywords:
Keratoacanthoma Clinical manifestation Pathological diagnosis
分类号:
R 739.5
DOI:
10.13735/j.cjdv.1001-7089.201610008
文献标志码:
B
摘要:
目的 了解角化棘皮瘤患者的临床表现和组织病理特点。方法 回顾性分析本科2012年1月-2016年8月经组织病理确诊的43例角化棘皮瘤患者的临床资料。结果 43例角化棘皮瘤患者中,男20例,女23例,均为单发皮损, 50岁以上40例(占93.02%),平均发病年龄(70.72±13.59)岁。皮损好发于头、面及四肢远端等暴露部位。3例早期皮损,39例成熟期皮损,1例消退期皮损。呈“火山口状”溃疡33例(76.74%)、皮角3例(6.98%)、角化过度30例(69.77%)、角化不全24例(55.81%)、角囊肿26例(60.47%)、毛玻璃样细胞20例(46.51%)、异型细胞18例(41.86%)、病理性核分裂相10例(23.26%)及真皮炎性细胞浸润34例(79.07%)。均予手术切除皮损,至今未见复发。本病临床与病理诊断符合率53.49%,易被误诊为皮肤鳞状细胞癌、寻常疣等。结论 角化棘皮瘤好发于中老年人群,单发性皮损手术治疗预后良好,皮损组织病理检查有助于鉴别诊断。
Abstract:
Objective To investigate the clinical and histopathological features of keratoacanthoma(KA).Methods Retrospective analysis was performed using the data of 43 outpatient cases of KA pathologically diagnosed from January 2012 to August 2016. Results Isolated leison occurred in all 43 cases including 20 cases of male and 23 cases of female.Those aged above 50 accounted for 93.02%(40/43),and the mean age of onset was(70.72±13.59)years.KA leisons exist in the head,face,distal extremities and other light-exposed parts.Three cases were early KA,39 cases were mature KA and one case was involuting KA.Respectively,KA was characterized by 33 cases(76.74%)of crateriform ulcer,3 cases(6.98%)of cornu cutaneum,30 cases(69.77%)of hyperkeratosis,24 cases(55.81%)of parakeratosis,26 cases(60.47%)of keratocyst,20 cases(46.51%)of glassy keratinocytes,18 cases(41.86%)of atypical cells,10 cases(23.26%)of pathological mitoses and 34 cases(79.07%)of inflammatory cells infiltrate in the dermis.All cases were conducted by surgical excision,with no recurrence followed up so far.The coincidence between clinical and pathological diagnosis was 53.49% in KA.Clinically KA can be easily misdiagnosed with cutaneous squamous cell carcinoma or verruca vulgaris.Conclusion KA occurs in the aged individuals.Surgical excision is recommended for single leison and the prognosis is fine.Histopathological examination can help to differentiate diagnosis.

参考文献/References:

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更新日期/Last Update: 2017-04-05