[1]李晓云,钮含春,田恒创,等.皮肌炎中医证型与调节性T淋巴细胞的相关性[J].中国皮肤性病学杂志,2017,(02):209-212,224.[doi:10.13735/j.cjdv.1001-7089.201606097]
　LI Xiao-yun,NIU Han-chun,TIAN Heng-chuang,et al.Relationship between TCM Syndrome and Regulatory T Cells in Peripheral Blood from Patients with Dermatomyositis[J].The Chinese Journal of Dermatovenereology,2017,(02):209-212,224.[doi:10.13735/j.cjdv.1001-7089.201606097]
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皮肌炎中医证型与调节性T淋巴细胞的相关性
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2017年02期
页码:
209-212,224
栏目:
中医中药
出版日期:
2017-02-01

文章信息/Info

Title:
Relationship between TCM Syndrome and Regulatory T Cells in Peripheral Blood from Patients with Dermatomyositis
作者:
李晓云1;  钮含春1;  田恒创1;  王春艳1 ; 韩允2; 许春艳2;  王晓军1
1.河北医科大学附属平安医院（石家庄平安医院）风湿科，河北 石家庄 050021； 2.河北省辛集市中医院；河北 辛集 252360
Author(s):
LI Xiao-yun1; NIU Han-chun1;  TIAN Heng-chuang1; WANG Chun-yan1; HAN Yun2; XU Chun-yuan2; WANG Xiao-jun1
1.Department of Rheumatology, Shijiazhuang Ping'an Hospital, Shijiazhuang 050021, China; 2.Xinji TCM Hospital of Hebei Province,Xinji 052360,China
关键词:
皮肌炎; 中医证型; 调节性T细胞
Keywords:
Dermatomyositis;  TCM Syndrome Types;  Regulatory T cells
分类号:
R 593.26
DOI:
10.13735/j.cjdv.1001-7089.201606097
文献标志码:
B
摘要:
目的 观察皮肌炎(DM)患者不同中医证型与外周血调节性T细胞（Treg）的关系。〖HTH〗方法 149例确诊DM的患者分为热毒炽盛证、湿热蕴结证、寒湿痹阻证、脾肾两虚证、肝肾阴虚证，采用流式细胞术检测外周血Treg比例，研究其与中医证型病情活动相关性。并设118例健康对照组。〖HTH〗结果 热毒炽盛证、湿热蕴结证患者血Treg百分率显著低于其他组，差异有统计学意义（P＜005）；寒湿痹阻证血Treg百分率低于脾肾两虚证、肝肾阴虚证、健康对照组，差异有统计学意义（P＜005）；脾肾两虚证、肝肾阴虚证患者血Treg百分率与健康对照组的比较差异无统计学意义（P＞005）。〖HTH〗结论 DM患者的中医证型与其免疫功能状态存在关联。
Abstract:
Objective To demonstrate the relationship between different TCM Syndrome Types and regulatory T cells(Treg) in peripheral blood from patients with dermatomyositisMethods One hundred and fortynine cases of patients with dermatomyositis were enrolled and divided into heattoxin flourishing syndrome, dampheat accumulation syndrome, colddampness obstruction syndrome , PiShen deficiency syndrome ,and GanShen yin deficiency syndrome Flow cytometry was used to detect the percentage of Treg in peripheral blood from 149 patients and 118 healthy controlsResults The percentages of Treg cells in patients with heattoxin flourishing syndrome, dampheat accumulation syndrome was much lower than those in other groups(P<005); Also the percentages of Treg cells in patients with colddampness obstruction syndrome were significantly lower than those in PiShen deficiency syndrome, GanShen yin deficiency syndrome, and healthy controls, respectively(P<005); There was no significant difference in percentages of Treg cells between PiShen deficiency syndrome, GanShen yin deficiency syndrome and healthy controls (P>005) Conclusion There was an definite association between TCM Syndrome Types and regulatory T cells (Treg) in patients with dermatomyositis.

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备注/Memo

备注/Memo:
[基金项目]河北省中医药管理局科研计划项目（2013223） [通讯作者]钮含春，E-mail:niuhanchun@126.com
更新日期/Last Update: 2017-02-10