SUN Kang-yue,LI Ying,SUN Ren-shan.Progress in Zika Virus,its Infection,Diagnosis and Therapy[J].The Chinese Journal of Dermatovenereology,2016,(12):1290-1292,1306.[doi:10.13735/j.cjdv.1001-7089.201606104]





Progress in Zika Virus,its Infection,Diagnosis and Therapy
[作者单位] 1.中南大学湘雅医学院第三附属医院内科教研室,湖南 长沙 410013; 2.第三军医 大学大坪医院皮肤科,重庆 400038
SUN Kang-yue1LI Ying1 SUN Ren-shan2
1.Department of Internal Medicine, the Third Affiliated Hospital,Xiangya Medical College, Central South University of China, Changsha 400013, China; 2.Department of Dermatology, Daping Hospital, Chongqing 400038,China
寨卡病毒 感染 诊断 治疗 进展
Zika virus Infection Diagnosis Therapy Progress
R 373
本文介绍了寨卡病毒的病原学特征,寨卡病毒感染的流行病学、临床表现和诊断治疗新 进展。寨卡病毒是一种单链RNA病毒,属黄病毒科黄病毒属成员。主要通过伊蚊叮咬传播,其他传 播方式还有性传播、血液传播、母婴传播。约20%感染者表现轻微症状,包括低热、斑丘疹、关 节疼痛、结膜炎等,严重者采用对症治疗。寨卡病毒感染引起关注的重要原因是其神经系统并发 症,包括吉兰巴雷综合征、孕妇感染引起胎儿的小头畸形等。确诊感染目前尚无金标准,主要是 采用RT-PCR检测血清、唾液、组织、尿液、全血中寨卡病毒RNA。
This review summarizes the etiology, epidemiology, clinical manifestations, diagnose and treatment of Zika virus(ZIKV)infection.ZIKV is a single-stranded RNA virus, belonging to a member of the genus Flavivirus in the family Flaviviridae.In addition to being transmitted by the Aedes mosquito to humans, the principal form of transmission, other uncommon transmission ways include blood, mother-baby and sexual contact.Only 20% of patients have mild symptoms, including fever, maculopapular rash, arthralgia, conjunctivitis, etc.Severe patients require symptomatic treatment.ZIKV infection has caught much attention because of the neurological complications, including Guillan Barré (GBS)syndrome and microcephalic infants prenatally exposed ZIKV.No gold standard for diagnosis is available.RT-PCR is the main diagnostic tool to detect Zika virus RNA in serum, saliva, tissues, urine, and whole blood sample.


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[基金项目] 中南大学创新创业项目(ZY2015796) [通讯作者] 李颖,E-mail:13538563@qq.com
更新日期/Last Update: 2016-12-20