[1]朱凤,陶迪生,张利,等.蜂针疗法对寻常性银屑病患者Th17的影响[J].中国皮肤性病学杂志,2016,(12):1282-1283,1289.[doi:10.13735/j.cjdv.1001-7089.201604141]
 ZHU Feng,TAO Di-sheng,ZHANG Li,et al.Influence of Bee Needle Therapy on Th17 in Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2016,(12):1282-1283,1289.[doi:10.13735/j.cjdv.1001-7089.201604141]
点击复制

蜂针疗法对寻常性银屑病患者Th17的影响
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年12期
页码:
1282-1283,1289
栏目:
中医中药
出版日期:
2016-12-20

文章信息/Info

Title:
Influence of Bee Needle Therapy on Th17 in Patients with Psoriasis Vulgaris
作者:
朱凤陶迪生张利陈兰朱玲玲
[作者单位] 南京中医药大学附属中西医结合医院,中国中医科学院江苏分院,江苏省中西医结 合医院,江苏 南京210028
Author(s):
ZHU FengTAO Di-shengZHANG Li CHEN LanZHU Ling-ling
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028,China
关键词:
银屑病寻常性 蜂针疗法 Th17细胞
Keywords:
Psoriasis ordinary type Bee acupuncture Th17 cells
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201604141
文献标志码:
B
摘要:
目的 观察蜂针疗法对寻常性银屑病患者Th17相关因子IL-17,IL-22,IL-23水平的影响 。方法 入选的30例寻常性银屑病(稳定期)患者,均为蜂针试验阴性或弱阳性者。选取10日龄以 上意大利蜂,用蜂量从2只开始,每1周治疗1次, 4周为1个疗程,共治疗2个疗程。治疗前后采用双 抗体夹心ELISA法,检测外周血Th17相关因子IL-17,IL-22,IL-23的水平。同时选择30例健康人为 对照组。结果 蜂针疗法后,银屑病患者外周血中IL-17,IL-23水平较治疗前有所下降,差异有统 计学意义(P均<0.05); IL-22水平较治疗前有所下降,差异无统计学意义 (P>0.05)。蜂疗结束后,有5例患者出现新的银屑病皮疹,皮疹主要分布在蜂疗外区域 ,占临床总有效患者的17.24%。结论 蜂针疗法治疗寻常性银屑病效果明显,能有效改善银屑病皮 损,蜂毒能有效降低银屑病患者血液中IL-17和IL-23的水平,通过降低IL-17的水平,促进皮损的 消退。蜂针疗法在治疗寻常性银屑病方面,疗效显著,副作用小,复发率低,值得临床上推广使用 。
Abstract:
Objective To investigate the effect of bee needle therapy on the expression of Th17 related cytokines(IL-17, IL-22, and IL-23)in patients with psoriasis vulgaris.Methods Thirty patients with stable psoriasis vulgaris and negative or weakly positive to bee needle test were enrolled.Patients were treated initially with two 10-day old Italian bees once weekly, 4 weeks/treatment course, for a total of 2 treatment courses.30 healthy volunteers served as controls.Double antibody sandwich ELISA method was used to measure expression levels of IL-17, IL- 22, IL-23 in peripheral blood before and after treatment.Results Bee needle therapy significantly lowered IL-17 and IL-23, not IL-22 levels, in peripheral blood of psoriatic patients(P < 0.05).After the therapy, 5 patients developed new psoriatic lesions out of the treated area, accounting for 17.24% of good responders.Conclusion Bee needle therapy is effective for psoriasis vulgaris.Bee venom can effectively lower IL-17 and IL-23 levels in peripheral blood of psoriatic patients.Reduction in IL-17 levels leads to clearance of psoriatic lesions.Bee needle therapy is safe and effective for psoriasis vulgaris with lower recurrence rate, it is worth to promote its clinical use.

参考文献/References:

[1] 赵辨.中国临床皮肤病学[M].江苏:江苏科学技术出版社,2009:1011-1012.
[2] 顾有守.中、重度银屑病的联合治疗[J].临床皮肤科杂志,2005,34(3):196-198.
[3] Yilmaz SB,Cicek N,Coskun M,et al.Serum and tissue levels of IL-17 in different clinical subtypes of psoriasis[J].Arch Dermatol Res,2012,304(6):465-469.
[4] Lowes MA,Kikuchi T,Fuentes-DuculanJ,et al.Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells[J].J Invest Dermatol,2008,128(5):1207 -1211.
[5] Chen X,Tan Z,Yu Q,et al.The expression of interleukin-23 and inteleukin-1 2 in psoriasis skin [J].Huazhong Univ Sei Teehnolog Med Sci,2006,26(6):750-752.
[6] 李万瑶.蜂针疗法[M].北京:人民卫生出版社,2003:22-24.

相似文献/References:

[1]戴莎,王秀丽,宋心葵,等.银屑病患者410例合并代谢综合征分析[J].中国皮肤性病学杂志,2012,(08):700.
 DAI Sha,WANG Xiu-li,SONG Xin-kui,et al.Analysis of 410 Cases of Psoriasis Patients with Metabolic Syndrome[J].The Chinese Journal of Dermatovenereology,2012,(12):700.
[2]谢韶琼,汪青良,宋勋,等.凉血润肤汤治疗寻常性银屑病42例疗效观察[J].中国皮肤性病学杂志,2012,(08):743.
 XIE Shao-qiong,WANG Qing-liang,SONG Xun,et al.Clinical Observation of Liangxierunfu Decoction on 42 Cases of Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2012,(12):743.
[3]广维,朱红,姚树兰,等.伊那西普治疗银屑病的十年回顾[J].中国皮肤性病学杂志,2012,(08):745.
 GUANG Wei,ZHU Hong,YAO Shu-lan,et al.A 10-year Review of Etanercept in the Treatment of Psoriasis[J].The Chinese Journal of Dermatovenereology,2012,(12):745.
[4]史航,刘晓明,林熙然,等.银屑病发病与创伤愈合机制的比较[J].中国皮肤性病学杂志,2012,(08):748.
 SHI Hang,LIU Xiao-ming,LIN Xi-ran.A Comparison on Pathogenesis of Psoriasis and Mechanism of Wound Healing[J].The Chinese Journal of Dermatovenereology,2012,(12):748.
[5]刘晓洁,张峻岭,刘雪,等.头皮银屑病和脂溢性皮炎的皮肤镜特征分析[J].中国皮肤性病学杂志,2015,(01):36.[doi:10.13735/j.cjdv.1001-7089.2015.0036]
 LIU Xiao jie,ZHANG Jun ling,LIU Xue,et al.Analysis of Dermoscopic Criteria for Scalp Psoriasis and Scalp Seborrheic Dermatitis[J].The Chinese Journal of Dermatovenereology,2015,(12):36.[doi:10.13735/j.cjdv.1001-7089.2015.0036]
[6]王彩梅,汤洁,向志,等.甲损害在泛发性脓疱型银屑病中的临床意义[J].中国皮肤性病学杂志,2015,(01):44.[doi:10.13735/j.cjdv.1001-7089.2015.0044]
 WANG Cai mei,TANG Jie,XIANG Zhi,et al.Clinical Significance of Nail Involvement in Generalized Pustular Psoriasis[J].The Chinese Journal of Dermatovenereology,2015,(12):44.[doi:10.13735/j.cjdv.1001-7089.2015.0044]
[7]李珺莹,李红.酪氨酸激酶及其抑制剂与免疫性皮肤病的研究进展[J].中国皮肤性病学杂志,2015,(01):93.[doi:10.13735/j.cjdv.1001-7089.2015.0093]
 LI Jun ying,LI Hong.Tyrosine Kinases and its Inhibitors in Immune Dermatologic Diseases[J].The Chinese Journal of Dermatovenereology,2015,(12):93.[doi:10.13735/j.cjdv.1001-7089.2015.0093]
[8]段茜,程燕,储蕾,等.银屑病与高血压病的相关性分析[J].中国皮肤性病学杂志,2015,(02):143.[doi:10.13735/j.cjdv.1001-7089.201404140]
 DUAN Xi,CHENG Yan,CHU Lei,et al.The Correlation between Psoriasis and Hypertension[J].The Chinese Journal of Dermatovenereology,2015,(12):143.[doi:10.13735/j.cjdv.1001-7089.201404140]
[9]杨颜龙,张禁,易松柏,等.阿维A胶囊联合复方甘草酸苷注射液治疗红皮病型银屑病30例临床观察[J].中国皮肤性病学杂志,2015,(02):217.[doi:10.13735/j.cjdv.1001-7089.201403167]
 YANG Yan long,ZHANG Jin,YI Song bai,et al.Clinical Observation of 30 Acitretin Capsules Combine with Compound Glycyrrhizin Injection in the Treatment of Patients with Erythrodermic Psoriasis[J].The Chinese Journal of Dermatovenereology,2015,(12):217.[doi:10.13735/j.cjdv.1001-7089.201403167]
[10]伍慧媚,吴玮,卢传坚,等.应用ClinProt技术筛查寻常性银屑病不同中医证型患者的相关蛋白表达特征[J].中国皮肤性病学杂志,2015,(03):304.[doi:10.13735/j.cjdv.1001-7089.201408030]
 WU Hui mei,WU Wei,LU Chuan jian,et al.Applying ClinProt Technology to Detect the Expression Characteristic of Proteins in Psoriatic Vulgaris with Different Syndrome Patterns[J].The Chinese Journal of Dermatovenereology,2015,(12):304.[doi:10.13735/j.cjdv.1001-7089.201408030]
[11]唐娟,张晓艳,宋佩华,等.寻常性银屑病患者皮损及外周血单一核细胞中IL-17A的表达[J].中国皮肤性病学杂志,2012,(08):689.
 TANG Juan,ZHANG Xiao-yan,SONG Pei-hua,et al.Expression of IL-17A in Involved Lesions and Blood Mononuclear Cells of Patients with Psoriaisis[J].The Chinese Journal of Dermatovenereology,2012,(12):689.
[12]孙景英,普雄明,吴卫东.CXCL9和Smad3在新疆维吾尔族寻常性银屑病患者皮损中的表达[J].中国皮肤性病学杂志,2015,(03):242.[doi:10.13735/j.cjdv.1001-7089.201407083]
 SUN Jing ying,PU Xiong ming,WU Wei dong.The Expression of CXCL9 and Smad3 in Psoriasis Vulgaris of Xinjiang Uyghur Patients[J].The Chinese Journal of Dermatovenereology,2015,(12):242.[doi:10.13735/j.cjdv.1001-7089.201407083]
[13]魏义花,付昱,蒋东英,等.甲氨蝶呤对寻常性银屑病患者血清IL-23,IL-17水平影响[J].中国皮肤性病学杂志,2015,(03):249.[doi:10.13735/j.cjdv.1001-7089.201407105]
 WEI Yi hua,FU Yu,JIANG Dong ying,et al.Effect of MTX on Serum Levels of IL23 and IL17 in the Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2015,(12):249.[doi:10.13735/j.cjdv.1001-7089.201407105]
[14]贺赛玉,杨慧兰,樊建勇,等.308nm准分子光联合钙泊三醇倍他米松治疗寻常性银屑病30例临床观察[J].中国皮肤性病学杂志,2015,(06):654.[doi:10.13735/j.cjdv.1001-7089.201405066]
 HE Sai yu,YANG Hui lan,FAN Jian yong,et al.Observation on the Efficacy of 308 nm Excimer Light Combined with Calcipotriol Betamethasone Ointment for Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2015,(12):654.[doi:10.13735/j.cjdv.1001-7089.201405066]
[15]辛忠,袁少飞,关敬之.银屑胶囊联合阿维A治疗寻常性银屑病临床观察及其对外周血细胞因子的影响[J].中国皮肤性病学杂志,2016,(09):988.[doi:10.13735/j.cjdv.10017089.201604156]
 XIN Zhong,YUAN Shao fei,GUAN Jing zhi.Effect of Yinxie Capsule and Acitretin on Psoriasis Vulgaris and its Cytokines in Peripheral Blood[J].The Chinese Journal of Dermatovenereology,2016,(12):988.[doi:10.13735/j.cjdv.10017089.201604156]
[16]李珺莹,李红,吉彬,等.清热解毒汤治疗血热型寻常性银屑病的疗效观察及对血清TNF-α的影响[J].中国皮肤性病学杂志,2017,(05):554.[doi:10.13735/j.cjdv.1001-7089.201608018]
 LI Jun-ying,LI Hong,JI Bin,et al.The Efficacy of QingReJieDu Decoction in the Treatment of Psoriasis Vulgaris with the Pattern of BloodHeat and the Influence on Level of TNFα in the Serum[J].The Chinese Journal of Dermatovenereology,2017,(12):554.[doi:10.13735/j.cjdv.1001-7089.201608018]
[17]刘磊,张晓彬,李振鲁.白芍总苷联合维A酸和糠酸莫米松治疗寻常性银屑病36例临床观察[J].中国皮肤性病学杂志,2014,(10):1097.[doi:10.13735/j.cjdv.1001-7089.2014.1097]
 LIU Lei,ZHANG Xiao-bin,LI Zhen-lu.Clinical Observation on Total Glucosides Paeony (TGP) in Combined with Tretinoin and Momestasone Furoate on Treatment of 36 Cases with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2014,(12):1097.[doi:10.13735/j.cjdv.1001-7089.2014.1097]
[18]吉燕,郭菲,刘红霞,等.新疆地区寻常性银屑病110例生活质量横断面调查[J].中国皮肤性病学杂志,2014,(06):606.[doi:10.13735/j.cjdv.1001-7089.2014.0606]
 JI Yan,GUO Fei,LIU Hong-xia,et al.Cross-sectional Study on Dermatology Life Quality Index in 110 Patients with Psoriasis Vulgaris in Xinjiang Area[J].The Chinese Journal of Dermatovenereology,2014,(12):606.[doi:10.13735/j.cjdv.1001-7089.2014.0606]
[19]陈慧君,陈治国.白芍总苷胶囊治疗前、后寻常性银屑病患者外周血IL-17,TNF-α和IFN-γ的变化[J].中国皮肤性病学杂志,2014,(02):135.
 CHEN Huijun,CHEN Zhiguo.The Levels of IL17,TNFα,IFNγ in the Serum in Patients with Psoriasis Vulgaris Before and After TGP Treatment[J].The Chinese Journal of Dermatovenereology,2014,(12):135.
[20]朱凤,朱黎明,李英,等.大黄蟅虫胶囊治疗血瘀型银屑病30例临床观察[J].中国皮肤性病学杂志,2014,(02):195.
 ZHU Feng,ZHU Liming,LI Ying,et al.Clinical Observation on 30 Cases with Blood Stasis Type Psoriasis Dahuang Zhechong Capsule[J].The Chinese Journal of Dermatovenereology,2014,(12):195.

备注/Memo

备注/Memo:
[基金项目] 江苏省中医药管理局项目(LZ13067) [通讯作者] 陶迪生,E-mail:tds2005800@126.com
更新日期/Last Update: 2016-12-20