[1]石建,高杰,包健安,等.卡马西平致重症药疹40例临床分析[J].中国皮肤性病学杂志,2016,(11):1142-1143,1146.[doi:10.13735/j.cjdv.1001-7089.201607127]
　SHI Jian,GAO Jie,BAO Jian-an,et al.Clinical Analysis of 40 Cases with Severe Drug Eruption Caused by Carbamazepine[J].The Chinese Journal of Dermatovenereology,2016,(11):1142-1143,1146.[doi:10.13735/j.cjdv.1001-7089.201607127]
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卡马西平致重症药疹40例临床分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年11期
页码:
1142-1143,1146
栏目:
临床经验
出版日期:
2016-11-01

文章信息/Info

Title:
Clinical Analysis of 40 Cases with Severe Drug Eruption Caused by Carbamazepine
作者:
石建; 高杰; 包健安; 缪丽燕
苏州大学附属第一医院药学部,江苏 苏州 215006
Author(s):
SHI Jian; GAO Jie; BAO Jian-an; MIAO Li-yan
Pharmacy Department of First Affiliated Hospital of Soochow University,Suzhou 215006 China
关键词:
卡马西平;  药疹;  基因
Keywords:
Carbamazepinel;  Drug eruption;  Gene
分类号:
R 758.25
DOI:
10.13735/j.cjdv.1001-7089.201607127
文献标志码:
B
摘要:
目的 了解卡马西平致重症药疹40例的临床特征,为临床合理用药提供参考依据。方法 对本院2005年1月-2015年12月收住院治疗的40例卡马西平致重症药疹病例资料进行回顾性分析,包括患者的基本情况(性别、年龄和严重皮肤不良反应的类型)、潜伏期、累及脏器与临床表现、住院时间费用及转归、HLA-B*1502等位基因检测结果。结果 40例患者中,>45 岁中老年患者比例最高(65%),潜伏期均较长,中位数为 17( 2 ～ 59)d; 除有皮肤损伤外,最常见黏膜受损(31.07%),其次为全身损害(25.24%)和血液系统损伤(18.45%); 平均住院时间为21.80d,与治疗费用高相关; HLA-B*1502等位基因阳性率高(93.75%)。结论 卡马西平致重症药疹危害大,治疗费用高,建议使用前进行相关基因检测,从而促进临床安全用药。
Abstract:
Objective To analyze the factors of severe cutaneous adverse reaction(SCAR)caused by carbamazepine,and to provide a rationale for clinical usage of drugs properly.Methods Data of 40 cases of hospitalized SCAR caused by carbamazepine from Jan.2005 to Dec.2015, at First Affiliated Hospital of Soochow University were retrospectively analyzed in terms of gender, age, type of SCAR,latency, organ involved and clinical manifestation, duration of hospitalization, cost of therapy, and HLA-B*1502 gene detection.Results Patients over 45 years old had the highest incidence of SCAR( 65%)and longer latency(ranging from 2 to 59 days,median latency of 17 days). Besides cutaneous involvement, mucosal damage was the most common(31.07%),followed by systemic damage(25.24%), and blood system(18.45%). The average duration of hospitalization was 21.8 days, which accounted for the high treatment cost. The positive rates of HLA-B*1502 allele were high(93.75%).Conclusion Severe cutaneous adverse reaction(SCAR)caused by carbamazepinel is serious and costly. Thus, gene analysis should be performed before prescribing carbamazepine to the patients to ensure it is safe to use.

参考文献/References:

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备注/Memo

备注/Memo:
[通讯作者] 缪丽燕,E-mail:miaolysuzhou@ 163.com
更新日期/Last Update: 2016-11-01