[1]王倩,刘伟,张丽霞,等.中性粒细胞/淋巴细胞比值与寻常性银屑病及银屑病关节炎的关系[J].中国皮肤性病学杂志,2016,(10):1017-1019,1023.[doi:10.13735/j.cjdv.1001-7089.201601143]
 WANG Qian,LIU Wei,ZHANG Li-xia,et al.The Relationship of Neutrophil to Lymphocyte Ratio with Psoriasis Vulgaris and Psoriasis Arthritis[J].The Chinese Journal of Dermatovenereology,2016,(10):1017-1019,1023.[doi:10.13735/j.cjdv.1001-7089.201601143]
点击复制

中性粒细胞/淋巴细胞比值与寻常性银屑病及银屑病关节炎的关系
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年10期
页码:
1017-1019,1023
栏目:
论著
出版日期:
2016-10-01

文章信息/Info

Title:
The Relationship of Neutrophil to Lymphocyte Ratio with Psoriasis Vulgaris and Psoriasis Arthritis
作者:
王倩刘伟张丽霞段西凌
四川省医学科学院·四川省人民医院皮肤性病研究所,四川 成都 610072
Author(s):
WANG Qian LIU Wei ZHANG Li-xia DUAN Xi-ling
The Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China
关键词:
寻常性银屑病 银屑病关节炎 中性粒细胞/淋巴细胞比值 炎症
Keywords:
Psoriasis vulgaris Psoriasis arthritis Neutrophil to lymphocyte ratio Inflammation
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201601143
文献标志码:
A
摘要:
目的 探讨中性粒细胞/淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)与寻常性银屑病及银屑病关节炎的关系。方法 回顾分析81例寻常性银屑病和17例银屑病关节炎的血常规指标、C反应蛋白(CRP)水平,计算中性粒细胞/淋巴细胞比值及血小板/淋巴细胞比值(platelet to lymphocyte ratio,PLR),并与60例正常人比较。采用Pearson相关分析了解CRP与NLR和PLR的相关性,用Logistic回归分析银屑病关节炎的相关变量,采用受试者工作特征曲线探讨NLR对银屑病关节炎的诊断效能。结果 寻常性银屑病患者血WBC,NEU和NLR较正常对照组升高(P均<0.05),银屑病关节患者血NEU,NLR和PLR较寻常性银屑病患者及正常对照均明显升高(P均<0.05)。Pearson相关分析显示寻常性银屑病患者血NLR与CRP成正相关(P<0.05)。Logistic回归分析结果显示NLR是银屑病关节炎的独立相关变量(P<0.05)。受试者工作特征曲线显示NLR为3.14时对银屑病关节炎的诊断效能最高,其敏感度为93.8%,特异性为76.6%。结论 寻常性银屑病及银屑病关节炎患者NLR较正常人明显升高,银屑病关节炎患者NLR,PLR明显高于寻常性银屑病患者。NLR对银屑病关节炎有较好的诊断效能。
Abstract:
Objective To explore the relationship of neutrophil to lymphocyte ratio(NLR)with psoriasis vulgaris(PsV)and psoriasis arthritis(PsA).Methods A retrospective analysis including 81 PsV patients, 17 PsA patients and 60 normalcontrols was done.The comparing parameters contained blood routine indexes, CRP,NLR and platelet to lymphocyte ratio(PLR).Pearson correlation analysis was used to detect the correlations.Logistic regression analysis was used to determine the variables associated with PsA.Receiver operating characteristic(ROC)curve was applied to ensure the diagnosis efficacy of NLR to PsA.Results WBC, NEU, NLR were significantly higher in PsV patients than in normal controls(P<0.05).NEU, NLR, PLR in PsA patients were significantly higher than in PsV patients and controls(P<0.05).There was a statistically significant correlation between NLR and CRP in PsV patients.Logistic regression analysis showed NLR was an independent related variable of PsA(P<0.05). ROC curve analysis revealed that the NLR value of 3.14 had the optimal diagnosis efficacy with sensitivity and specificity of 93.8% and 76.6%.Conclusion NLR was significantly higher in PsV and PsA patients.NLR, PLR in PsA patients even higher than in PsV patients.NLR had a potential diagnosis efficacy to PsA.

参考文献/References:

[1] Taylor W, Gladman D, Helliwell P, et al.Classification criteria for psoriatic arthritis: development of new criteria from a large international study [J].Arthritis Rheum, 2006, 54(8):2665-2673.
[2]Li R, Sun J, Ren LM, et al.Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing[J].Rheumatology(Oxford), 2012, 51(4):721-729.
[3]Ogdie A, Yu Y, Haynes K, et al.Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis:a population-based cohort study[J].Ann Rheum Dis, 2015, 74(2):326-332.
[4]Wiedow O, Wiese F, Christophers E.Lesional elastase activity in psoriasis.Diagnostic and prognostic significance[J].Arch Dermatol Res, 1995, 287(7):632-635.
[5]Orem A, Deger O, Cimsit G, et al.Plasma polymorphonuclear leukocyte elastase levels and its relation to disease activity in psoriasis[J].Clin Chim Acta, 1997, 264(1):49-56.
[6]Mee JB, Cork MJ, di Giovine FS, et al.Interleukin-1: a key inflammatory mediator in psoriasis[J].Cytokine, 2006, 33(2):72-78.
[7]Eder L, Thavaneswaran A, Chandran V, et al.Increased burden of inflammation over time is associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis[J].Ann Rheu Dis, 2015, 74(10):1830-1835.
[8] Sen N, Afsar B, Ozcan F, et al.The neutrophil to lymphocyte ration was associated with impaired myocardial perfusion and long term adverse outcome in patients with ST-elevated myocardial infarction undergoing primary coronary intervention [J].Atherosclerosis,2013, 228(1):203-210.
[9] Buyukkaya E, Karakas MF, Karakas E, et al.Correlation ofneutrophiltolymphocyteratiowith the presence and severity ofmetabolicsyndrome[J].Clin Appl Thromb Hemost, 2014, 20(2):159-163.
[10] Li C, Wen TF, Yan LN, et al.Postoperativeneutrophil-to-lymphocyteratioplusplatelet-to-lymphocyteratiopredicts the outcomes of hepatocellular carcinoma [J].J Surg Res, 2015, 198(1):73-79.
[11] Qin B, Ma N, Tang Q, et al.Neutrophiltolymphocyteratio(NLR),platelettolymphocyteratio(PLR)wereusefulmarkersin assessmentof inflammatoryresponseand diseaseactivityinSLEpatients[J].Mod Rheumatol, 2016, Mar 4:1-5.[Epub ahead of print]
[12] Fu H, Qin B, Hu Z, et al.Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis[J].Clin Lab, 2015, 61(3-4):269-273.
[13]Kim DS, Shin D, Lee MS, et al.Assessments of neutrophil to lymphocyte ratio in Korea patients with psoriasis vulgaris and psoriatic arthritis[J].J Dermatol, 2016, 43(3):305-310.
[14] Sen BB, Rifaioglu EN, Ekiz O, et al.Neutrophil to lymphocyte ratio as a measure of systemic inflammation in psoriasis [J].Cutan Ocul Toxicol, 2014, 33(3):223-227.
[15] Yurtdas M, Yaylali YT, Kaya Y, et al.Neutrophil-to-lymphocyte ration may predict subclinical atherosclerosis in patients with psoriasis [J].Echocardiography, 2014, 31(9):1095-1104.
[16] Furst DE, Kay J, Wasko MC, et al.The effect of golimumab on haemoglobin levels in patients with rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis [J].Rheumatology(Oxford), 2013, 52(10):1844-1855.

相似文献/References:

[1]刘玉林,刘春,张娟.自拟凉血润燥汤治疗血热风燥型寻常性银屑病95例临床观察[J].中国皮肤性病学杂志,2015,(08):853.[doi:10.13735/j.cjdv.1001-7089.201411143]
 LIU Yu lin,LIU Chun,ZHANG Juan.Clinical Observation of 95 Cases of Psoriasis Vulgaris of Blood Hot Air Drying Type Treated by Self Cooling Blood Runzao Decoction[J].The Chinese Journal of Dermatovenereology,2015,(10):853.[doi:10.13735/j.cjdv.1001-7089.201411143]
[2]隆岚,李振,钱振云,等.阿维A对寻常性银屑病患者CCL2和CCR2水平的影响[J].中国皮肤性病学杂志,2015,(10):1019.[doi:10.13735/j.cjdv.1001.7089.201503125]
 LONG Lan,LI Zhen,IAN Zhen yun,et al.Effects of Acitretin on CCL2 and CCR2 Levels in Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2015,(10):1019.[doi:10.13735/j.cjdv.1001.7089.201503125]
[3]余晓玲,方凯,晋红中.寻常性银屑病合并良性型组织细胞吞噬性脂膜炎1例[J].中国皮肤性病学杂志,2015,(11):1167.[doi:10.13735/j.cjdv.1001-7089.201411001]
 YU Xiao ling,FANG Kai,JIN Hong zhong.A Case of Psoriasis Vulgaris Complicated with Benign Cytophagichistiocyticpanniculitis[J].The Chinese Journal of Dermatovenereology,2015,(10):1167.[doi:10.13735/j.cjdv.1001-7089.201411001]
[4]邢立亚,高丽琴,贾静,等.寻常性银屑病患者外周血单个核细胞肝脏X受体β的表达[J].中国皮肤性病学杂志,2016,(06):579.[doi:10.13735/j.cjdv.1001-7089.201511097]
 XING Li-ya,GAO Li-qin,JIA Jing,et al.Expression of Liver X Receptor β in Peripheral Blood Mononuclear Cells of Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2016,(10):579.[doi:10.13735/j.cjdv.1001-7089.201511097]
[5]郭衡山,于雅洁,张小芳,等.寻常性银屑病合并大疱性类天疱疮1例[J].中国皮肤性病学杂志,2016,(06):607.[doi:10.13735/j.cjdv.1001-7089.201510081]
 GUO Heng-shan,YU Ya-jie,ZHANG Xiao-fang,et al.A Case of Coexistence of Psoriasis Vulgaris and Bullous Pemphigoid[J].The Chinese Journal of Dermatovenereology,2016,(10):607.[doi:10.13735/j.cjdv.1001-7089.201510081]
[6]刘爱民,崔利莎,张步鑫,等.麻防犀角地黄汤与犀角地黄汤治疗冬季血热型银屑病的疗效观察[J].中国皮肤性病学杂志,2016,(06):629.[doi:10.13735/j.cjdv.1001-7089.201510007]
 LIU Ai-min,CUI Li-sha,ZHANG Bu-xin,et al.Observation of Clinical Curative Effect of Mafang Xijiao Dihuang Decoction and Xijiao Dihuang Decoction in Treating Winter Psoriasis Vulgaris with Blood-Heat Syndrome[J].The Chinese Journal of Dermatovenereology,2016,(10):629.[doi:10.13735/j.cjdv.1001-7089.201510007]
[7]房婕,陈榕,刘莹,等.寻常性银屑病患者外周血髓源性抑制细胞的检测及其与Th17细胞的相关性[J].中国皮肤性病学杂志,2016,(09):902.[doi:10.13735/j.cjdv.1001-7089.201603008]
 FANG Jie,CHEN Rong,LIU Ying,et al.Detection of Myeloid-Derived Suppressor Cells in the Peripheral Blood of Patients with Psoriasis Vulgaris and its Correlation with Th17 Cells[J].The Chinese Journal of Dermatovenereology,2016,(10):902.[doi:10.13735/j.cjdv.1001-7089.201603008]
[8]靳亚莉,张振国,乐宏元,等.寻常性银屑病患者血清中抗两种分枝杆菌LAM抗原抗体的检测[J].中国皮肤性病学杂志,2016,(11):1104.[doi:10.13735/j.cjdv.1001-7089.201604143]
 JIN Ya-li,ZHANG Zhen-guo,YUE Hong-yuan,et al.Detections of Antibodies Against Two Kinds of LAM Antigens of Mycobacteria in Serum from Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2016,(10):1104.[doi:10.13735/j.cjdv.1001-7089.201604143]
[9]杨志波,唐雪勇,王畅.miR-199a抑制低氧诱导因子在银屑病患者皮损中的表达[J].中国皮肤性病学杂志,2017,(07):709.[doi:10.13735/j.cjdv.1001-7089.201611038]
 YANG Zhi-bo,TANG Xue-yong,WANG Chang.Role of miR-199a in Inhibiting the Expression of Hypoxia-inducible Factor in Psoriasis[J].The Chinese Journal of Dermatovenereology,2017,(10):709.[doi:10.13735/j.cjdv.1001-7089.201611038]
[10]房慧媚,贾瑞璇,李凤迪,等.凉血消风汤对血热型寻常性银屑病患者外周血淋巴细胞乙酰化内稳态的影响[J].中国皮肤性病学杂志,2017,(09):1021.[doi:10.13735/j.cjdv.1001-7089.201702014]
 FANG Hui-mei,JIA Rui-xuan,LI Feng-di,et al.The Effect of Liangxue Xiaofeng Tang on Acetylation Homeostasis of Patients with Blood Heat Type Psoriasis[J].The Chinese Journal of Dermatovenereology,2017,(10):1021.[doi:10.13735/j.cjdv.1001-7089.201702014]

备注/Memo

备注/Memo:
[通讯作者] 张丽霞, E-mail:274248110@qq.com
更新日期/Last Update: 2016-10-20