[1]辛忠,袁少飞,关敬之.银屑胶囊联合阿维A治疗寻常性银屑病临床观察及其对外周血细胞因子的影响[J].中国皮肤性病学杂志,2016,(09):988-990.[doi:10.13735/j.cjdv.10017089.201604156]
 XIN Zhong,YUAN Shao fei,GUAN Jing zhi.Effect of Yinxie Capsule and Acitretin on Psoriasis Vulgaris and its Cytokines in Peripheral Blood[J].The Chinese Journal of Dermatovenereology,2016,(09):988-990.[doi:10.13735/j.cjdv.10017089.201604156]
点击复制

银屑胶囊联合阿维A治疗寻常性银屑病临床观察及其对外周血细胞因子的影响
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年09期
页码:
988-990
栏目:
药物与临床
出版日期:
2016-09-01

文章信息/Info

Title:
Effect of Yinxie Capsule and Acitretin on Psoriasis Vulgaris and its Cytokines in Peripheral Blood
作者:
辛忠1袁少飞1关敬之2
1.包头医学院第二附属医院药剂科,内蒙古 包头 014030;2.内蒙古国际蒙医医院, 内蒙古 呼和浩特 010065
Author(s):
XIN Zhong1YUAN Shao fei1GUAN Jing zhi2
1 Pharmaceutical Department, the Second Affiliated Hospital of Baotou Medical College, Baotou 014030, China;2 Pharmaceutical Department, Inner Mongolia International Mongolian Hospital, Hohhot 010065, China
关键词:
银屑胶囊寻常性银屑病细胞因子
Keywords:
Yinxie capsule Psoriasis vulgaris Cytokines 
分类号:
R 758.63
DOI:
10.13735/j.cjdv.10017089.201604156
文献标志码:
B
摘要:
目的.观察银屑胶囊联合阿维A胶囊治疗寻常性银屑病的临床疗效及其对外周血细胞因子水平的影响。〖HTH〗方法.将90例寻常性银屑病患者根据随机数字表法分为两组,全部患者予阿维A胶囊口服,治疗组同时予银屑胶囊口服,比较两组患者的临床疗效及其外周血白介素2(IL2),IL4,IL10,IL17,IL23及转化生长因子β(TGFβ1)的水平。〖HTH〗结果.治疗结束后,治疗组患者PASI评分(3.62±2.03)及血清IL2,IL17和IL23水平均明显低于对照组PASI评分(6.22±2.33)及血清IL2,IL17和IL23水平,治疗组有效率(42.22%)及血清IL4,IL10和TGFβ1水平均明显高于对照组有效率(20.00%)及血清IL4,IL10和TGFβ1水平,前述差异均有统计学意义(P均<0.05)。〖HTH〗结论.银屑胶囊联合阿维A胶囊治疗寻常性银屑病临床疗效显著,其可能通过降低炎性细胞因子IL2,IL17,IL23水平及提高IL4,IL10和TGFβ1水平发挥作用。
Abstract:
Objective〖WTBZ〗〓To observe the efficacy of Yinxie capsules and acitretin capsules for psoriasis vulgaris and their effects on cytokines in peripheral blood 〖WTHZ〗Methods〖WTBZ〗〓Ninty patients with psoriasis vulgaris were randomly divided into two groups The control group orally took acitretin capsules alone, and the treatment group took both Yinxie capsules and acitretin capsules The clinical efficacy and the serum levels of IL2, IL4, IL10, IL17, IL23 and TGFβ1 were compared between the two groups 〖WTHZ〗Results〖WTBZ〗〓After treatment, the PASI scores, and the serum levels of IL2, IL17 and IL23 were significantly lower in the treatment group than in the controls (PASI cores 362±203 for the treatment group and 622±233 for the controls, P<005 for all parameters between the groups) The efficacy, and the serum levels of IL4, IL10 and TGFβ1 were significantly higher in the treatment group than in the controls (effective rate 42.22% for the treatment group and 20.00% for the controls, P<005 for all parameters between the groups)〖WTHZ〗Conclusion〖WTBZ〗〓Combination of Yinxie capsules and acitretin capsules is effective for psoriasis vulgaris, possibly resulting from the reduction in serum levels of IL2, IL17 and IL23, and increase in the serum levels of IL4, IL10 and TGFβ1

参考文献/References:

[1] 赵娜,吴卫志,杨平,等.银屑病流行病学研究进展[J].山东医药,2013,53(39):95-97.
[2] 秦思,温炬,郑荣昌,等.T细胞在银屑病与特应性皮炎发病机制中的研究进展[J].广东医学,2013,34(7):1126-1129.
[3] 张江安,于建斌.银屑胶囊联合阿维A胶囊治疗寻常性银屑病的临床观察[J].中国皮肤性病学杂志,2012,26(3):279-280.
[4] 侯绍伟,王红梅,周登远.基于聚类分析的银屑病中医证候研究[J].中国皮肤性病学杂志,2015,29(10):1080-1081.
[5] 谢秀丽.寻常型银屑病中医证候诊断标准研究[D].广州.广州中医药大学,2015.
[6] 王泉丽,张改连,张莉芸,等.Th17/Th1细胞及相关细胞因子在银屑病关节炎中的研究进展[J].中华风湿病学杂志,2013,17(12):840-843.
[7] 苏彤,陈宏,李璐,等.寻常性银屑病患者外周血白介素17、白介素23 mRNA的表达及与病情相关性研究[J].中华皮肤科杂志,2014,47(4):278-281.
[8] 赵京霞,王燕,底婷婷,等.IL23/IL17轴在银屑病免疫发病机制中的作用[J].基础医学与临床,2012,32(4):453-456.
[9] 李睿亚,段妍,莎娜,等.免疫三氧自血疗法治疗寻常型银屑病疗效及外周血IL17/IL23的水平研究[J].内蒙古医学杂志,2015,47(5):529-532.〖ZK)〗
[10] 樊卓,覃静净,王丹丹,等.阿维 A胶囊对寻常型银屑病患者外周血 I-TAC表达的影响[J].广西医学,2014,9(11):1622-1624.

相似文献/References:

[1]唐娟,张晓艳,宋佩华,等.寻常性银屑病患者皮损及外周血单一核细胞中IL-17A的表达[J].中国皮肤性病学杂志,2012,(08):689.
 TANG Juan,ZHANG Xiao-yan,SONG Pei-hua,et al.Expression of IL-17A in Involved Lesions and Blood Mononuclear Cells of Patients with Psoriaisis[J].The Chinese Journal of Dermatovenereology,2012,(09):689.
[2]孙景英,普雄明,吴卫东.CXCL9和Smad3在新疆维吾尔族寻常性银屑病患者皮损中的表达[J].中国皮肤性病学杂志,2015,(03):242.[doi:10.13735/j.cjdv.1001-7089.201407083]
 SUN Jing ying,PU Xiong ming,WU Wei dong.The Expression of CXCL9 and Smad3 in Psoriasis Vulgaris of Xinjiang Uyghur Patients[J].The Chinese Journal of Dermatovenereology,2015,(09):242.[doi:10.13735/j.cjdv.1001-7089.201407083]
[3]魏义花,付昱,蒋东英,等.甲氨蝶呤对寻常性银屑病患者血清IL-23,IL-17水平影响[J].中国皮肤性病学杂志,2015,(03):249.[doi:10.13735/j.cjdv.1001-7089.201407105]
 WEI Yi hua,FU Yu,JIANG Dong ying,et al.Effect of MTX on Serum Levels of IL23 and IL17 in the Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2015,(09):249.[doi:10.13735/j.cjdv.1001-7089.201407105]
[4]贺赛玉,杨慧兰,樊建勇,等.308nm准分子光联合钙泊三醇倍他米松治疗寻常性银屑病30例临床观察[J].中国皮肤性病学杂志,2015,(06):654.[doi:10.13735/j.cjdv.1001-7089.201405066]
 HE Sai yu,YANG Hui lan,FAN Jian yong,et al.Observation on the Efficacy of 308 nm Excimer Light Combined with Calcipotriol Betamethasone Ointment for Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2015,(09):654.[doi:10.13735/j.cjdv.1001-7089.201405066]
[5]张同梅,于倩,葛明盖,等.疗癣卡西甫丸与银屑胶囊对咪喹莫特诱导小鼠银屑病样皮损的影响[J].中国皮肤性病学杂志,2015,(11):1115.[doi:10.13735/j.cjdv.1001-7089.201502083]
 ZHANG Tong mei,YU Qian,GE Ming gai,et al.Effect of LiaoxuanKaxipu Pill and Yinxie Capsule on Psoriasis Mice Model Induced by Imiquimod[J].The Chinese Journal of Dermatovenereology,2015,(09):1115.[doi:10.13735/j.cjdv.1001-7089.201502083]
[6]朱凤,陶迪生,张利,等.蜂针疗法对寻常性银屑病患者Th17的影响[J].中国皮肤性病学杂志,2016,(12):1282.[doi:10.13735/j.cjdv.1001-7089.201604141]
 ZHU Feng,TAO Di-sheng,ZHANG Li,et al.Influence of Bee Needle Therapy on Th17 in Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2016,(09):1282.[doi:10.13735/j.cjdv.1001-7089.201604141]
[7]李珺莹,李红,吉彬,等.清热解毒汤治疗血热型寻常性银屑病的疗效观察及对血清TNF-α的影响[J].中国皮肤性病学杂志,2017,(05):554.[doi:10.13735/j.cjdv.1001-7089.201608018]
 LI Jun-ying,LI Hong,JI Bin,et al.The Efficacy of QingReJieDu Decoction in the Treatment of Psoriasis Vulgaris with the Pattern of BloodHeat and the Influence on Level of TNFα in the Serum[J].The Chinese Journal of Dermatovenereology,2017,(09):554.[doi:10.13735/j.cjdv.1001-7089.201608018]
[8]杜金锋,裴广德,甄希,等.甘草锌颗粒联合异维A酸红霉素凝胶治疗轻、中度寻常性痤疮72例临床观察[J].中国皮肤性病学杂志,2013,(09):900.
 DU Jinfeng,PEI Guangde,ZHEN Xi,et al.Clinical Effect of Licorzine Granules United Isotretinoin Erythromycin Eel for 72 Cases of Acne Vulgaris[J].The Chinese Journal of Dermatovenereology,2013,(09):900.
[9]刘磊,张晓彬,李振鲁.白芍总苷联合维A酸和糠酸莫米松治疗寻常性银屑病36例临床观察[J].中国皮肤性病学杂志,2014,(10):1097.[doi:10.13735/j.cjdv.1001-7089.2014.1097]
 LIU Lei,ZHANG Xiao-bin,LI Zhen-lu.Clinical Observation on Total Glucosides Paeony (TGP) in Combined with Tretinoin and Momestasone Furoate on Treatment of 36 Cases with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2014,(09):1097.[doi:10.13735/j.cjdv.1001-7089.2014.1097]
[10]吉燕,郭菲,刘红霞,等.新疆地区寻常性银屑病110例生活质量横断面调查[J].中国皮肤性病学杂志,2014,(06):606.[doi:10.13735/j.cjdv.1001-7089.2014.0606]
 JI Yan,GUO Fei,LIU Hong-xia,et al.Cross-sectional Study on Dermatology Life Quality Index in 110 Patients with Psoriasis Vulgaris in Xinjiang Area[J].The Chinese Journal of Dermatovenereology,2014,(09):606.[doi:10.13735/j.cjdv.1001-7089.2014.0606]

备注/Memo

备注/Memo:
[通讯作者] 袁少飞,Email:yuanshaofei1984@163.com
更新日期/Last Update: 2016-09-20