[1]章若画,闵仲生.SAPHO综合征16例临床分析[J].中国皮肤性病学杂志,2016,(09):911-914.[doi:10.13735/j.cjdv.1001-7089.201603016]
 ZHANG Ruo-hua,MIN Zhong-sheng.The Clinical Features of SAPHO Syndrome:16 Cases Report[J].The Chinese Journal of Dermatovenereology,2016,(09):911-914.[doi:10.13735/j.cjdv.1001-7089.201603016]
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SAPHO综合征16例临床分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年09期
页码:
911-914
栏目:
临床经验
出版日期:
2016-09-01

文章信息/Info

Title:
The Clinical Features of SAPHO Syndrome:16 Cases Report
作者:
章若画闵仲生
南京中医药大学附属医院皮肤科,江苏 南京 210029
Author(s):
ZHANG Ruo-hua MIN Zhong-sheng
Department of Dermatology,Affiliated Hospital of Nanjing University of Chinese Traditional Medicine,Nanjing 210029,China
关键词:
SAPHO综合征 掌跖脓疱病 胸锁关节骨肥厚症
Keywords:
SAPHO syndrome Palmoplantar pustulosis Sternocostoclavicular hyperostosis
分类号:
R 751; R 681
DOI:
10.13735/j.cjdv.1001-7089.201603016
文献标志码:
B
摘要:
目的 分析SAPHO综合征的临床特征,提高临床医生对本病的认识。方法 对16例SAPHO综合征患者的一般资料、临床表现、实验室检查及治疗等进行分析。结果 16例SAPHO综合征患者中,男9例,女7例。掌跖脓疱病14例,重度痤疮2例。胸锁肋关节受累16例,骶髂关节炎10例,僵硬的脊柱骨肥厚4例,周围关节炎11例。C-反应蛋白和血沉轻度升高各9例。以非甾体类抗炎药联合白芍总苷及中药治疗有一定疗效。结论 SAPHO综合征以皮肤病变和骨关节病变为主要临床表现。非甾体类抗炎药、白芍总苷及相关中药可有效缓解骨关节疼痛和皮损。
Abstract:
Objective This study aimed to summarize the clinical features of 16 cases of synovitis acne pustulosis hyperostosis osteomyelitis(SAPHO)syndrome, and to improve the recognition of this disease.Medthods General data, clinical features, physical and chemical examination, and therapeutic outcome of 16 cases were analyzed. Results Sixteen patients included 9 males and 7 females. Dermatological manifestations included palmoplantar pustulosis in 14 patients and severe acne in 2 patients. Osteoarticular involvements included sternoclavicular joint in 16 patients, sacroiliitis in 10 patients, vertebral column in 4 patients, and peripheral polyarthritis in 11 patients. 9 patients displayed an elevated level of both C-reactive protein and erythrocyte sedimentation rate. Nonsteroidal anti-inflammatory drug(NSAIDs)combined with total glucosides of paeony and traditional chinese medicines were effective for this disease.Conclusion Skin and joint involvements were the common clinical manifestations. NSAIDs, total glucosides of paeony and traditional chinese medicines improved both cutaneous and osteoarticular lesions.

参考文献/References:

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备注/Memo

备注/Memo:
[通讯作者] 闵仲生,E-mail:minzhsh@sina.com
更新日期/Last Update: 2016-09-20