[1]谢湘江,赵京霞-,底婷婷,等.抗菌肽LL-37在银屑病发病机制中的作用[J].中国皮肤性病学杂志,2016,(07):748-750.[doi:10.13735/j.cjdv.1001-7089.201510022]
　XIE Xiang-jiang,ZHAO Jing-xia-,DI Ting-ting,et al.Antimicrobial Peptides LL-37 in the Immunopathogenesis of Psoriasis[J].The Chinese Journal of Dermatovenereology,2016,(07):748-750.[doi:10.13735/j.cjdv.1001-7089.201510022]
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抗菌肽LL-37在银屑病发病机制中的作用
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年07期
页码:
748-750
栏目:
综述
出版日期:
2016-07-01

文章信息/Info

Title:
Antimicrobial Peptides LL-37 in the Immunopathogenesis of Psoriasis
作者:
谢湘江1; 赵京霞2-4; 底婷婷1; 2; 王 燕1; 2; 李 萍1-4
1.北京中医药大学,北京100010; 2.银屑病中医临床基础研究北京市重点实验室,北京100010; 3.北京市中医研究所,北京100010; 4.首都医科大学附属北京中医医院,北京100010
Author(s):
XIE Xiang-jiang1;  ZHAO Jing-xia2-4;  DI Ting-ting1; 2;  WANG Yan1; 2; LI Ping1-4
1.Beijing University of Chinese Medicine, Beijing 100010,China; 2.Beijing Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on Psoriasis,Beijing 100010,China; 3.Beijing Institute of Traditional Chinese Medicine,Beijing 100010,China; 4.Beijing Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University,Beijing 100010,China
关键词:
LL-37;  抗菌肽;  银屑病
Keywords:
LL-37;  Cathelicidin;  Psoriasis
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201510022
文献标志码:
B
摘要:
银屑病是一种以T淋巴细胞异常活化和浸润为主要特征的慢性炎性反应皮肤病。抗菌肽LL-37的表达在银屑病的发病机制中可能处于上游地位,并成为新的治疗靶标。LL-37过度表达可导致浆细胞样树突状细胞异常活化,并激活Th1,Th17细胞与角质形成细胞间的循环刺激网络,是银屑病皮损炎症反应持续存在的重要基础。 [关键词] LL-37; 抗菌肽; 银屑病
Abstract:
Psoriasis is a chronic inflammatory skin disease characterized by abnormal activated T cells infiltration.Recently,LL-37 has been recognized as an upper position and potential therapeutic target in psoriasis.Overexpression of LL-37 in psoriasis leads to abnormal activation of plasmacytoid dendritic cells and the formation of stimulation loop between Th cells(Th1 and Th17 cells)and kerotinocyte.This is one of important foundations of persist out inflammation in psoriasis lesions.

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更新日期/Last Update: 2016-07-10