[1]叶振源,涂云华,薛月萃,等.乳房外Paget病误诊为湿疹1例[J].中国皮肤性病学杂志,2016,(04):422-423,425.[doi:10.13735/j.cjdv.1001-7089.201501049]
 YE Zhen yuan,TU Yun hua,XUE Yue cui,et al.A Case report of Misdiagnosis of Extramammary Paget's Disease[J].The Chinese Journal of Dermatovenereology,2016,(04):422-423,425.[doi:10.13735/j.cjdv.1001-7089.201501049]
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乳房外Paget病误诊为湿疹1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年04期
页码:
422-423,425
栏目:
误诊教训
出版日期:
2016-04-01

文章信息/Info

Title:
A Case report of Misdiagnosis of Extramammary Paget's Disease
作者:
叶振源涂云华薛月萃申小平魏羽佳陆洪光曹煜
贵州医科大学附属医院皮肤科 贵州 贵阳 550000
Author(s):
YE ZhenyuanTU YunhuaXUE Yuecui SHENG XiaopingWEI YujiaLU Hongguang CAO Yu
Department of Dermatology and Venereology,the Affiliated Hospital of Guiyang Medical University,Guiyang 550000,China
关键词:
Paget病乳房外
Keywords:
Paget's diseaseextrammary
分类号:
R 739.5
DOI:
10.13735/j.cjdv.1001-7089.201501049
文献标志码:
B
摘要:
患者男,65岁。阴囊部红斑伴瘙痒11年余。曾多次以湿疹治疗,无明显好转。4个月前出现糜烂、渗出,并伴有明显恶臭,予以手术切除。皮损组织病理:表皮内可见呈巢的Paget细胞,真皮可见累及,基底部皮损未发现肿瘤细胞,切缘见肿瘤累及。免疫组化:CKL(+),CEA(+),MelanA(-),HMB45(-),EMA(+),GCDEP(+),CK5/6(-),CK7(+),CK20(-),p53(+),p63(-),ki67阳性率约10%~20%。诊断:乳房外Paget病。
Abstract:
A 65-year-old male patient suffered from a skin disease of scrotum erythema along with itching for more than 11 years. He was treated as eczema several times without obvious improvement.Four months ago erosion, exudation and odor were developed. Lesion resection was considered. Histopathology showed nests of paget cells in the epidermis and involvement of the dermis. Tumor cells were absence in the skin lesions but seen in the deep leion. Immunohistochemistry finding: CKL(+), CEA(+), MelanA(-), HMB-45(-), EMA(+), GCDEP(+),CK5/6(-),CK7(+),CK20(-),p53(+),p63(-),ki6710%~20%. Diagnosis:extramammary Paget's disease.

参考文献/References:

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[3] 聂廷芬,周之海.乳房外paget病免疫组化研究进展[J].国际皮肤性病学杂志,2007,33(5):309-310.
[4] 王侠生,廖康煌.杨国亮皮肤病学[M].上海:上海科学技术文献出版社,2005:994.
[5] Park S, Grossfeld GD, Mcaninch JW,et al.Extramammary Paget’s disease of the penis and scrotum: excision, reconstruction, and evaluation of occult malignancyComment[J].J Urol, 2001, 166(6): 2112-2117.

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更新日期/Last Update: 2016-04-20