[1]崔文颖,高艳青,李海燕.HIV/AIDS合并药疹47例住院患者临床分析[J].中国皮肤性病学杂志,2015,(11):1162-1164,1171.[doi:10.13735/j.cjdv.1001-7089.201501018]
　CUI Wen ying,GAO Yan qing,LI Hai yan.A Clinical Analysisof 47 HIV/AIDS Inpatient With Drug Eruption[J].The Chinese Journal of Dermatovenereology,2015,(11):1162-1164,1171.[doi:10.13735/j.cjdv.1001-7089.201501018]
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HIV/AIDS合并药疹47例住院患者临床分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年11期
页码:
1162-1164,1171
栏目:
性传播疾病
出版日期:
2015-11-01

文章信息/Info

Title:
A Clinical Analysisof 47 HIV/AIDS Inpatient With Drug Eruption
作者:
崔文颖; 高艳青; 李海燕
首都医科大学附属北京佑安医院皮肤性病科，艾滋病研究北京市重点实验室，北京100069
Author(s):
CUI Wen ying ; GAO Yan qing ; LI Hai yan
Beijing Youan Hospital,Capital Medical University,Beijing Municipal Key Laboratory of AIDS Research，Beijing 100069,China
关键词:
HIV; AIDS;  药疹;  CD4+计数; 回顾性研究
Keywords:
HIV; AIDS;  Drug eruption ;  CD4+ count;  Retrospective study
分类号:
R512.91
DOI:
10.13735/j.cjdv.1001-7089.201501018
文献标志码:
B
摘要:
目的 探讨HIV/AIDS合并药疹住院患者的CD4+ T淋巴细胞水平与临床特征、实验室检查 、转归及愈后的关系。方法 收集本院47例住院HIV/AIDS合并药疹患者的临床资料，回顾性分析患者的一般资料、致敏药物、药疹 类型、实验室检查及疾病转归情况，重点分析CD4+计数＜ 200 个 /μL组与CD4+ 计数＞200 个 /μL组的异同。结果 CD4+计数＜ 200 个/μL组患者重症药疹发生率为4828%，合并电解质紊乱的发生率为5172%、合并感染率为6207%，平均住院日为19 63天，皮疹消退时间为2381天，死亡率为2069%，而CD4+ 计数＞200 个 /μL组患者重症药疹的发生率为1111%、合并电解质紊乱的 发生率为2222%、合并感染率为1111%，平均住院日为1152天，皮疹消退时间为1732天，死亡率为556%，二者差异有统计学意义（P ＜005）。而二者在在肝功能受累、是否使用激素治疗情况差异无统计学意义（P＞005）。继发感染引起的死亡占总死亡率的7143%。〖 HTH〗结论 CD4+计数＜ 200 个/μL组HIV/AIDS 患者较CD4+ 计数＞200 个 /μL组HIV/AIDS 患者重症药疹的发生率更高、 更易合并电解质紊乱、感染，并且平均住院日与皮疹消退时间更长，死亡率更高；继发感染是主要死因，早期及时的对症治疗、防治继发感染很重 要。
Abstract:
Objective To investigate the relationship between CD4+ T lymphocyte count and clinical features, laboratory features,prognosis of the HIV/AIDS inpatient with drug eruptionsMethods Fortyseven cases of HIV/AIDS inpatient with drug eruption were collected and demographic data,laboratory examination,clinical manifestation, prognosis were analyzedespecially the differences between the patients with CD4+ count＜ 200 cells/μL and the patients with CD4+ count＞ 200 cells/μLResults Among patients whose CD4+ count＜ 200 cells/μL,the incidence rate of severe drug eruption was 4828%,and rate of combined electrolyte imbalance was 5172%,merge infection rate was 6207%,average length of stay was 1963 days ,average rash fade time was 2381 days,mortality was 2069%However，in patients whose CD4+ count＞ 200 cells/μL ,the incidence rate of severe drug eruption was 1111%,and rate of combined electrolyte imbalance was 2222%,merge infection rate was 1111%,average length of stay was 1152 days ,average rash fade time was 1732 days,mortality was 556%there was significant difference between the two groups (P<005)The results showed no significant difference between the two groups in liver involvement and whether to use hormone therapy (P>2005) Mortality rate caused by secondary infection was 7143% of the total mortalityConclusion Compare with the CD4+ count＞ 200 cells/μL patients,the patients with CD4+ count＜ 200 cells/μL are more frequently to suffer severe drug eruption,electrolyte imbalance and infection,and have longer averagelength of stay ,the death rate is higher, secondary infection was the main cause of deathTimely treatment and prevent infection are important

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更新日期/Last Update: 2015-11-20