[1]陈宇,花志祥,李隽,等.乳房外Paget病皮损中P27和细胞周期蛋白E表达[J].中国皮肤性病学杂志,2015,(11):1127-1129.[doi:10.13735/j.cjdv.1001-7089.201408052]
 CHEN Yu,HUA Zhi xiang,LI Jun,et al.Expression and Significance of P27 and CyclinE in Extramammary Paget’s Disease[J].The Chinese Journal of Dermatovenereology,2015,(11):1127-1129.[doi:10.13735/j.cjdv.1001-7089.201408052]
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乳房外Paget病皮损中P27和细胞周期蛋白E表达
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年11期
页码:
1127-1129
栏目:
论著
出版日期:
2015-11-01

文章信息/Info

Title:
Expression and Significance of P27 and CyclinE in Extramammary Paget’s Disease
作者:
陈宇花志祥李隽黄红娟施伟伟施健
江苏省南通市第一人民医院皮肤性病科,江苏 南通 226001
Author(s):
CHEN YuHUA Zhi xiangLI JunHUANG Hong juanSHI Wei weiSHI Jian
Department of Dermatology,the First People’ Hospital of Nantong,Nantong 226001,China
关键词:
P27细胞周期蛋白EPaget病乳房外免疫组织化学
Keywords:
P27CyclinE Paget’s diseaseExtramammary Immunohistochemistry
分类号:
R7395
DOI:
10.13735/j.cjdv.1001-7089.201408052
文献标志码:
A
摘要:
目的 探讨P27和细胞周期蛋白E在乳房外Paget病中的表达特点及其意义。方法 应用免疫组化二步法分别检测30例乳房外Paget病患者皮损及20例正常对照皮肤中P27和细胞周期蛋白E的表达情况。结果 P27在乳房外Paget病组织中表达低于正常皮肤组织(χ2=7031,P<005);细胞周期蛋白E在乳房外Paget病组织中表达高于正常皮肤组织(χ2=27648,P<005)。P27和细胞周期蛋白E呈负相关关系(r=-0437,P<005)。P27的表达与淋巴结转移无关(χ2=0621,P>005),细胞周期蛋白E的表达与淋巴结转移有关(χ2=6102,P<005)。结论 P27的低表达和细胞周期蛋白E的过表达在乳房外Paget病的发生发展中可能起着十分重要的作用,并且细胞周期蛋白E与乳房外Paget病的淋巴结转移有关。
Abstract:
Objective To examine the expression and significance of P27 and cyclinE in extramammary Paget’s disease (EMPD)Methods It was used to detect the distribution and expression of P27 and cyclinE in 30 patients with EMPD and in 20 patients with normal control skin by immunohistochemistryResults The positive rates of P27 and cyclinE expression in EMPD were 4333% and 8000% respectivelyThe expression of P27 was apparently lower in EMPD compared to normal skin tissues (χ2=7031,P<005),whereas the expression of cyclinE was higher in EMPD than that in normal skin tissues (χ2=27648,P<005)There was a negative correlation between P27 and cyclinE (P<005)The expression of P27 not related with lymph node metastasis,whereas the expression of cyclinE correlated with lymph node metastasisConclusion Underexpression of P27 and overexpression of cyclinE may contribute to the pathogenesis of EMPDFurthermore,the expression of cyclinE is correlated with lymph node metastasis

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更新日期/Last Update: 2015-11-20