[1]马毳毳,刘艳,尹佳锋,等.皮肤科住院患者血清铁蛋白及鳞状上皮细胞癌抗原的检测[J].中国皮肤性病学杂志,2015,(10):1023-1025,1028.[doi:10.13735/j.cjdv.1001.7089.201412150]
 MA Cui cui,LIU Yan,YIN Jia feng,et al.Detection of Serum Ferritin and Squamous Cell Carcinoma Antigen in Hospitalized Patients[J].The Chinese Journal of Dermatovenereology,2015,(10):1023-1025,1028.[doi:10.13735/j.cjdv.1001.7089.201412150]
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皮肤科住院患者血清铁蛋白及鳞状上皮细胞癌抗原的检测
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年10期
页码:
1023-1025,1028
栏目:
论著
出版日期:
2015-10-01

文章信息/Info

Title:
Detection of Serum Ferritin and Squamous Cell Carcinoma Antigen in Hospitalized Patients
作者:
马毳毳刘艳尹佳锋杨生莲赵波
西安交通大学医学院第二附属医院皮肤科,陕西 西安 710004
Author(s):
MA Cui cuiLIU YanYIN Jia fengYANG Sheng lianZHAO Bo
The Second Affiliated Hospital of Xi’an Jiaotong University,College of Medicine,Xi’an 710004
关键词:
铁蛋白鳞状上皮细胞癌抗原结缔组织病皮肌炎银屑病红皮病
Keywords:
FETSCCAConnective tissue disordersDermatomyositisPsoriasisPsoriasis
分类号:
R 751
DOI:
10.13735/j.cjdv.1001.7089.201412150
文献标志码:
A
摘要:
目的观察皮肤科住院患者血清铁蛋白(FET)、血清鳞状上皮细胞癌抗原(SCCA)水平变化情况及其意义。 方法对入选的514例皮肤科住院患者进行血清FET和SCCA检测,并随机选取同期其它科室住院患者514例作为对照组,比较两组患者血清FET和SCCA值。 结果皮肤科住院患者组血清FET升高129例(2510%),SCCA升高257例(5000%),对照组患者血清FET升高6例(117%),SCCA升高8例(156%)。FET检测结果:红斑狼疮(4/7)、多形红斑(3/6)、皮肌炎(19/40)、荨麻疹(11/25)、带状疱疹(27/95)、硬皮病(3/14)等的血清FET值有所升高。SCCA检测结果:银屑病(92/96)、湿疹(21/22)、红皮病(24/26)、泛发性神经性皮炎(6/7)、嗜酸性粒细胞增多性皮病(7/9)、毛发红糠疹(3/4)等的血清SCCA值升高明显。皮肤肿瘤患者血清FET值正常,血清SCCA值升高(3/6)。 结论结缔组织病类疾病、多形红斑、荨麻疹、带状疱疹可出现血清FET值升高。鳞状上皮增生明显、伴有大量鳞屑的皮肤病血清SCCA值可能升高。血清FET和SCCA值不是常见皮肤肿瘤(除皮肤鳞癌)的特异性指标。
Abstract:
Objective To examine the serum FET and SCCA levels of patients with skin diseases and their clinical significance.MethodsThe serum FET and SCCA levels of 514 cases of hospitalized patients in our department and 514 cases of eligible patients of other departments were detected and analyzed.ResultsThe number and percentage of patients with skin diseases who had higher serum FET and SCCA levels were 129(2510%)and 257 (5000%), respectively,significantly higher than those of the control group. The serum FET levels of connective tissue disorders also increased . The serum SCCA levels of psoriasis (92/96), eczema (21/22), erythrodermia(24/26), generalized neurodermatitis (6/7), hypereosinophilic dermatopathy (7/9),pityriasis rubra pilaris (3/4) increased significantly. The serum FET and SCCA levels of skin cancer had no obvious change.ConclusionThe serum FET levels of connective tissue disorders might rise. Squamous cell hyperplasia accompanied by a large scaly skin disease had higher serum SCCA level, especially in the erythroderma, psoriasis, hypereosinophilic dermatopathy, and dermatitis. The higher serum FET and SCCA levels were not a common skin cancer specific indicator (except for SCC).

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备注/Memo

备注/Memo:
[基金项目]西安交大院科技骨干项目(RC(GG)201204),多发性家族性毛发上皮瘤基因突变及临床研究
更新日期/Last Update: 2015-10-25