[1]李丹,曾碧冰,张峰,等.临床无肌病性皮肌炎12例临床分析及抗MDA5抗体对其预后的影响[J].中国皮肤性病学杂志,2015,(09):917-918,923.[doi:10.13735/j.cjdv.1001-7089.201502002]
　LI Dan,ZENG Bi bing,ZHANG Feng,et al.Clinical Analysis of 12 Clinical Amyopathic Dermatomyositis and the Influence of Anti MDA5 to Prognosis[J].The Chinese Journal of Dermatovenereology,2015,(09):917-918,923.[doi:10.13735/j.cjdv.1001-7089.201502002]
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临床无肌病性皮肌炎12例临床分析及抗MDA5抗体对其预后的影响
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年09期
页码:
917-918,923
栏目:
临床经验
出版日期:
2015-09-01

文章信息/Info

Title:
Clinical Analysis of 12 Clinical Amyopathic Dermatomyositis and the Influence of Anti MDA5 to Prognosis
作者:
李丹; 曾碧冰; 张峰; 李俊杰
东莞市人民医院皮肤科，广东 东莞 523059
Author(s):
LI Dan; ZENG Bi bing; ZHANG Feng; LI Jun jie
Department of Dermatology and Venereology,Dongguan People's Hospital,Dongguan 523059,China
关键词:
临床无肌病性皮肌炎; 皮肌炎; 肿瘤; 抗MDA5抗体
Keywords:
Clinical amyopathic dermatomyositis; Dermatomyositis; Malignancy; Serum anti MDA5 antibody(melanoma differentiation associated gene 5)
分类号:
R 593.26
DOI:
10.13735/j.cjdv.1001-7089.201502002
文献标志码:
B
摘要:
目的探讨临床无肌病性皮肌炎（CADM）的临床特征及抗MDA5抗体对其预后的影响。方法回顾性分析12例CADM患者的临床资料，并检测其中10例存活者的抗MDA5抗体。结果12例CADM患者均出现皮肌炎特征性的皮肤改变，6例合并肺间质病变，其中抗MDA5抗体阳性4例。6例继发恶性肿瘤。结论CADM无明显的肌病表现，但可累及内脏，易出现恶性肿瘤，抗MDA抗体阳性的CADM患者常伴有间质性肺炎，这对其预后有重要意义，应提高对此病的认识。
Abstract:
Objective To investigate the clinical feature,diagnosis,treatment and prognosis of clinical amyopathic dermatomyositis(CADM),and the influence of anti MDA5 to prognosis. Methods The clinical data on 12 patients were retrospectively reviewed according to the criteria of CADM proposed by Euwer.Serum anti MDA5 antibody levels from 10 CADM patients were detected by ELISA using recombinant melanoma differentiation associated gene 5(rMDA 5). Results All the 12 patients presented characteristic skin lesions.Interstitial lung disease(ILD) occurred in 6 patients in whom anti MDA5 antibody was positive in 4 patients.There were six patients with malignancy. Conclusion Although CADM has no manifestations of myopathy,internal organ might be involved,malignancy often appeared in CADM.Serum anti MDA5 antibody positive patients have more ILD，which had the very important ingfluence to the prognosis.We should enhance the understanding of CADM.

参考文献/References:

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更新日期/Last Update: 2015-09-25