[1]赵晓宣,杨国玲,甘红婉,等.背部隆突性皮肤纤维肉瘤1例[J].中国皮肤性病学杂志,2015,(08):842-844.[doi:10.13735/j.cjdv.1001-7089.201406049]
 ZHAO Xiao xuan,YANG Guo ling,GAN Hong wan,et al.A Case of Dermatofibrosarcoma Protuberans on Back[J].The Chinese Journal of Dermatovenereology,2015,(08):842-844.[doi:10.13735/j.cjdv.1001-7089.201406049]
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背部隆突性皮肤纤维肉瘤1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年08期
页码:
842-844
栏目:
病例报告
出版日期:
2015-08-01

文章信息/Info

Title:
A Case of Dermatofibrosarcoma Protuberans on Back
作者:
赵晓宣杨国玲甘红婉韩世新张芳芳
赵晓宣,杨国玲,甘红婉,韩世新,张芳芳
Author(s):
ZHAO XiaoxuanYANG GuolingGAN HongwanHAN ShixinZHANG Fangfang
Department of Dermatology,First Affiliated Hospital of Dalian Medical University,Dalian 116011,China
关键词:
隆突性皮肤纤维肉瘤背部
Keywords:
Dermatofibrosarcoma protuberans Back
分类号:
R 739.5
DOI:
10.13735/j.cjdv.1001-7089.201406049
文献标志码:
B
摘要:
患者女,48岁。23年前患者无意中发现背部绿豆大肿物,皮肤色,质软,略隆起,无自觉症状,未予重视。6年前肿物逐渐增大至1.5cm×1.5cm,浅红色,仍无自觉症状。1年前肿物颜色逐渐加深至暗紫色,触之有浸润感伴间断疼痛而就诊。皮损组织病理示:表皮轻度增生,真皮见大量异型梭形细胞,异型细胞呈短梭形,核大,深染,胞浆丰富,核浆比例增大,呈车辐状或漩涡状排列,侵袭性生长。免疫组织化学染色:CD34(+),HMB45(-),Ki67(<3%+),SMA(-),Vimentin(+)。诊断:隆突性皮肤纤维肉瘤。行手术切除治疗。
Abstract:
A 48yearold female presented with a small mass on the upper part of the back for 23 years, which was beanlike in appearance, soft in consistency and non tender. Its colour was normal.But since the last six years the mass gradually increased in size (1.5cm×1.5cm) and changed its colour to bright red. However, the colour of mass turned dark purple and occasionally painful one year ago. The skin biopsy result revealed large number of spindle cells in fullthickness dermis forming a storiform pattern, or a car wheel pattern. The nucleus was large, hyperchromatic with abundant cytoplasm, and increased ratio of nucleus and cytoplasm. Immunohistochemical staining showed: CD34(+),HMB45(-),Ki67(<3%+),SMA(-),Vimentin(+).The diagnosis of dermatofibrosarcoma protuberans was made. A complete surgery was done

参考文献/References:

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[7] Rutkowski P, Glabbeke MV, Rankin CJ, et al. Imatinib mesylate in advanced dermatofibrosarcoma protuberans:pooled analysis of two phaseⅡclinical trials[J]. J Clin Oncol, 2010,28(10):1772-1779.
[8] Giacchero D,Maire G,Nuin PA,et al.No correlation between the molecular subtype of COL1A1PDGFB fusion gene and the clinico histopathological features of dermatofibrosarcoma protuberans[J]. Invest Dermatol, 2010,130(3):904-907.
[9] 刘宝珩, 阎衡, 郝飞, 等.隆突性皮肤纤维肉瘤2例[J].中国皮肤性病学杂志, 2010, 24(1):67-68.

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更新日期/Last Update: 2015-08-25