[1]陶思铮,白劲松,李重熙,等.高效抗逆转录病毒治疗艾滋病患者临床毒副作用及疗效动态观察[J].中国皮肤性病学杂志,2015,(03):267-270.[doi:10.13735/j.cjdv.1001-7089.201402030]
 TAO Si zheng,BAI Jin song,LI Chong xi,et al.Observation of Side Effects and Curative Effect in AIDS Patients Treated by HAART[J].The Chinese Journal of Dermatovenereology,2015,(03):267-270.[doi:10.13735/j.cjdv.1001-7089.201402030]
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高效抗逆转录病毒治疗艾滋病患者临床毒副作用及疗效动态观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年03期
页码:
267-270
栏目:
性传播疾病
出版日期:
2015-03-01

文章信息/Info

Title:
Observation of Side Effects and Curative Effect in AIDS Patients Treated by HAART
作者:
陶思铮1白劲松2李重熙2郭应武2李玉叶1
1.昆明医科大学第一附属医院皮肤性病科/云南省皮肤性病研究所,云南 昆明 650031;2.昆明市第三人民医院感染一科,云南 昆明 650041
Author(s):
TAO Sizheng1 BAI Jinsong2 LI Chongxi2 GUO Ying wu2 LI Yuye1
1.The Dermatology Department of First Affiliated Hospital of Kunming Medical University / The Dermatology and Venereology Institute of Yunnan, Kunming 650031, China; 2. The First Infection Department of Third People's Hospital of Kunming, Kunming 650041, China
关键词:
艾滋病HAART临床毒副作用疗效动态监测
Keywords:
AIDS HAART Clinical side effects Therapy Dynamic monitor
分类号:
R 512.91
DOI:
10.13735/j.cjdv.1001-7089.201402030
文献标志码:
B
摘要:
目的了解高效抗逆转录病毒治疗(HAART)临床毒副作用及疗效的动态变化情况。方法分析2011年4-8月昆明市第三人民医院门诊初治艾滋病患者的背景资料、实验室检查、临床毒副作用、治疗方案变更情况。结果共入组73例,16例(21.92%)出现临床毒副作用,29例(39.73%)合并肝炎病毒。最常见的临床毒副作用为骨髓抑制(12.33%),其次为肝毒性(10.96%)、药疹(5.48%)、末梢神经炎(5.48%)、乳酸酸中毒(1.37%,死亡)和脂肪萎缩(1.37%)。随着年龄增大,临床毒副作用发生率越高。CD4+T淋巴细胞数计数分别在0~6月、6~12月和12~24月平均上升94.0cell/μL、44.3cell/μL和34.7cell/μL。静脉吸毒的艾滋病患者治疗后CD4+T淋巴细胞计数上升幅度小于其他传播途径的患者。结论接受HAART治疗的艾滋病患者临床毒副作用发生率高,是导致患者死亡的重要原因,需密切监测。
Abstract:
ObjectiveTo understand dynamic variation of side effects and curative effect among AIDS patients treated by highly active antiretroviral therapy (HAART). MethodsAll AIDS patients visited the Outpatient Clinic, the Third People’s Hospital of Kunming from April 2011 to August 2011 were analyzed, including background information, laboratory tests, side effects, alteration of therapeutic regimen. ResultsSeventy three AIDS patients were enrolled. Amongst them, 16 (21.92%)patients had side effects and 29(39.73%)patients were coinfected with hepatitis virus. The most common side effect was myelosuppression (12.33%), followed by live damage (10.96%), drug eruption (5.48%), peripheral neuritis (5.48%), lactic acidosis (1.37%,death)and lipoatrophy (1.37%). With age increasing, the incidence of side effect was higher. The CD4+T lymphocyte counts had respectively increased to 94cell/μL,44.3cell/μL and 34.7cell/μL during 0 to 6 months, 6 to 12 months and 12 to 24 months, respectively. The CD4+T lymphocyte counts of AIDS patients infected by intravenous drug user had less increase than others. ConclusionClinical side effect was frequent among AIDS patients treated by HAART. These are important causes of death and should be monitored closely.

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备注/Memo

备注/Memo:
[基金项目] 云南省科技厅项目(2010CD153、2011CI046);云南省卫生厅项目(D201234)
更新日期/Last Update: 2015-03-25