[1]魏义花,付昱,蒋东英,等.甲氨蝶呤对寻常性银屑病患者血清IL-23,IL-17水平影响[J].中国皮肤性病学杂志,2015,(03):249-250,257.[doi:10.13735/j.cjdv.1001-7089.201407105]
 WEI Yi hua,FU Yu,JIANG Dong ying,et al.Effect of MTX on Serum Levels of IL23 and IL17 in the Patients with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2015,(03):249-250,257.[doi:10.13735/j.cjdv.1001-7089.201407105]
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甲氨蝶呤对寻常性银屑病患者血清IL-23,IL-17水平影响
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年03期
页码:
249-250,257
栏目:
论著
出版日期:
2015-03-01

文章信息/Info

Title:
Effect of MTX on Serum Levels of IL23 and IL17 in the Patients with Psoriasis Vulgaris
作者:
魏义花1付昱2蒋东英3杨爽1付文静1王静1舒春梅1马蕾1李海英1张玉杰1
1.滨州医学院附属医院皮肤科,山东 滨州 256603;2.武汉市第一医院皮肤科,湖北 武汉 430022;3.滨州医学院附属医院耳鼻喉科,山东 滨州 256603
Author(s):
WEI Yihua1FU Yu2JIANG Dongying3YANG Shuang1FU Wenjing1WANG Jing1 SHU Chunmei1 MA Lei1LI Haiying1ZHANG Yujie1
1.Department of Dermatology,the Affiliated Hospital of Binzhou Medical College, Binzhou 256603,China;2. Department of Dermatology ,First Hospital of Wuhan, Wuhan 430022,China; 3.E.N.T department, the Affiliated Hospital of Binzhou Medical College, Binzhou 256603,China
关键词:
银屑病寻常性甲氨蝶呤IL23IL17
Keywords:
Psoriasis vulgarisMethotrexateIL23IL17
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201407105
文献标志码:
A
摘要:
目的探讨甲氨蝶呤(MTX)治疗寻常性银屑病(PV)的疗效及对患者血清IL23,IL17的影响,进一步阐明MTX治疗PV的作用机制。方法应用ELISA方法检测42例寻常性银屑病患者经MXT治疗前后血清IL23,IL17水平变化,并与41例正常对照组比较。结果MTX治疗寻常性银屑病疗效显著,治疗后PASI评分显著下降(P<0.01)。患者血清IL23,IL17水平分别为(1581.16±463.31)ng/L和(7.44±2.36)ng/L,显著高于正常对照组的(832.41±309.16)ng/L和(2.93±0.85)ng/L,差异有统计学意义(P<0.01)。MTX治疗后患者血清IL23,IL17水平分别为(845.68±385.95)ng/L和(3.04±0.79)ng/L,与治疗前相比显著下降,差异有统计学意义(P<0.01),且患者血清IL23,IL17水平与银屑病PASI评分均呈显著正相关(P<0.01)。结论MTX治疗寻常性银屑病疗效显著,可能通过调节Th17细胞降低血清IL23,IL17水平发挥治疗作用。
Abstract:
ObjectiveTo investigate the therapeutic effect of methotrexate (MTX) on psoriasis vulgaris (PV), study the effect of MTX on serum levels of IL23 and IL17, and further clarify the mechanism of MTX. MethodsSerum levels of IL23 and IL17 in 42 patients with PV (before and after treatment by MTX) and 41 healthy controls were measured by ELISA. ResultsThe mean PASI scores were significantly decreased after treatment with MTX (P<0.01). Serum levels of IL23 and IL17 of PV patients were 1561.91±501.84 ng/L and 7.87±2.41 ng/L, respectively. Which were both significantly higher than those in healthy controls (796.59±342.61 ng/L and 2.91±0.71 ng/L,P<0.01). After treatment with MTX,Serum levels of IL23 and IL17 of PV patients were 845.68±385.95 ng/L and 3.04±0.79 ng/L, respectively. Which were both significantly decreased than those before treatment. Serum levels of IL23 and IL17 of PV patients were both associated with PASI (P<0.01). ConclusionMTX is significantly effective in the treatment of PV. It may affect serum levels of IL23 and IL17 by regulating Th17 cells to play a role in the treatment of psoriasis.

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备注/Memo

备注/Memo:
[基金项目]山东省医药卫生科技发展计划项目(2014WS0191);滨州市科技发展计划项目(政策引导类)(2014ZC0125);滨州医学院附属医院青年骨干医师培养计划项目(201306)
更新日期/Last Update: 2015-03-25