[1]孙景英,普雄明,吴卫东.CXCL9和Smad3在新疆维吾尔族寻常性银屑病患者皮损中的表达[J].中国皮肤性病学杂志,2015,(03):242-245.[doi:10.13735/j.cjdv.1001-7089.201407083]
 SUN Jing ying,PU Xiong ming,WU Wei dong.The Expression of CXCL9 and Smad3 in Psoriasis Vulgaris of Xinjiang Uyghur Patients[J].The Chinese Journal of Dermatovenereology,2015,(03):242-245.[doi:10.13735/j.cjdv.1001-7089.201407083]
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CXCL9和Smad3在新疆维吾尔族寻常性银屑病患者皮损中的表达
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年03期
页码:
242-245
栏目:
论著
出版日期:
2015-03-01

文章信息/Info

Title:
The Expression of CXCL9 and Smad3 in Psoriasis Vulgaris of Xinjiang Uyghur Patients
作者:
孙景英1普雄明2吴卫东2
1. 新疆石河子大学医学院,新疆 石河子 832002;2. 新疆维吾尔自治区人民医院,新疆 乌鲁木齐 830001
Author(s):
SUN Jingying1 PU Xiongming2 WU Weidong2
1.Medical College of Shihezi University, Shihezi 832002, China; 2. Department of Dermatology, Xinjiang Autonomous Region Hospital, Urumqi 830001, China
关键词:
银屑病寻常性维吾尔族JAK/STATCXCL9Smad3
Keywords:
Psoriasis vulgaris Uyghur JAK/STATCXCL9Smad3
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201407083
文献标志码:
A
摘要:
目的比较新疆维吾尔族寻常性银屑病患者皮损及正常维吾尔族人群皮肤中CXCL9和Smad3的表达差异。方法Envision免疫组化法分别检测新疆维吾尔族寻常性银屑病患者皮损及正常人皮肤中CXCL9和Smad3的表达情况。结果与维吾尔族人群正常皮肤相比,CXCL9在寻常性银屑病皮损中的表达明显增加,主要以真皮乳头顶端为主,且差异具有明显统计学意义(χ2=17.874,P<0.01);Smad3在寻常性银屑病皮损中主要表达于细胞浆和细胞核,与正常皮肤中Smad3的表达相比,χ2=0.000,P>0.05,差异无统计学意义。结论新疆维吾尔族寻常性银屑病皮损中CXCL9蛋白表达升高,通过JAK/STAT信号通路在寻常性银屑病的炎症反应中发挥重要作用。
Abstract:
Objection To compare the expression differences of CXCL9 and Smad3 between psoriasis vulgaris lesions of Xinjiang Uygur patients and normal skin of Uygur people. Methods Using envision immunohistochemical method to detect the expression of CXCL9 and Smad3 in skin lesion of Xinjiang Uygur psoriasis vulgaris patients and in normal skin, respectively. ResultsIn comparison with normal skin, the expression of CXCL9 in the skin lesions of Xinjiang Uyghur psoriasis vulgaris patients was obviously increased, mainly expressing in the top of the dermal papilla and the basal layer, and differences were statistically significant (χ2=17.874,P<0.01). The expression of Smad3 was significantly downregulated compared to normal skin tissues, and mainly located in the cytoplasm and cell nucleus with no statistically significant difference (χ2=0.000,P>0.05). ConclusionThe expression of CXCL9 in the lesions of Xinjiang Uygur psoriasis vulgaris patients were upregulated, and may contribute to the inflammatory response in paoriasis vulgaris via the JAK/STAT signal pathway.

参考文献/References:

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更新日期/Last Update: 2015-03-25