[1]李路,沈孟奇,陈永艳,等.早期潜伏梅毒患者外周血单个核细胞中转录因子Foxp3 mRNA的表达[J].中国皮肤性病学杂志,2015,(03):239-241.[doi:10.13735/j.cjdv.1001-7089.201407080]
 LI Lu,SHEN Meng qi,CHEN Yong yan,et al.Expressions ofTranscription Factor Foxp3 mRNA in Peripheral Blood Mononuclear Cells from Patients with Primary Latent Syphilis[J].The Chinese Journal of Dermatovenereology,2015,(03):239-241.[doi:10.13735/j.cjdv.1001-7089.201407080]
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早期潜伏梅毒患者外周血单个核细胞中转录因子Foxp3 mRNA的表达
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年03期
页码:
239-241
栏目:
论著
出版日期:
2015-03-01

文章信息/Info

Title:
Expressions ofTranscription Factor Foxp3 mRNA in Peripheral Blood Mononuclear Cells from Patients with Primary Latent Syphilis
作者:
李路沈孟奇陈永艳雷微边可
遵义医学院附属医院皮肤科,贵州 遵义 563003
Author(s):
LI LuSHEN MengqiCHEN YongyanLEI WeiBIAN Ke
Department of Dermatology, Affiliated hospital of Zunyi Medical College, Zunyi 563000, China
关键词:
梅毒Foxp3 mRNA外周血单个核细胞
Keywords:
Syphilis Foxp3 mRNA PBMCs
分类号:
R 759.1
DOI:
10.13735/j.cjdv.1001-7089.201407080
文献标志码:
A
摘要:
目的探讨转录因子Foxp3在早期潜伏梅毒免疫致病机制中的作用。方法采用实时荧光定量PCR法检测32例早期潜伏梅毒患者和32例正常人对照组外周血单个核细胞(PBMCs)中Foxp3 mRNA的表达水平。结果早期潜伏梅毒患者Foxp3 mRNA的表达水平为(4.99±3.53),其表达水平高于正常对照组(1.13±0.55),两者比较差异有统计学意义(P<0.001)。但其与血清RPR滴度之间不存在相关关系 (P>0.05)。结论转录因子Foxp3的高表达可能在早期潜伏梅毒的免疫发病机制中具有重要作用。
Abstract:
ObjectiveTo investigate the roles of Foxp3 in the immunological pathogenesis of patients with primary latent syphilis. MethodsSYBR Green I Realtime fluorescence quantitative RTPCR was employed to detect the expression of Foxp3 mRNA in peripheral blood mononuclear cells from 32 patients with primary latent syphilis and 32 healthy controls. Resultsthe expression level of Foxp3 mRNA in patients and the control group were (4.99±3.53) and (1.13±0.55), respectively. The expression level of Foxp3 mRNA in patients with primary latent syphiliswas significantly higher than that in the healthy controls (P<0.001). No corelationship between expression levels of Foxp3 mRNA and serum RPR titers was found (P>0.05). ConclusionThe high expressions of Foxp3 genes may play important roles in immunological pathogenesis of patients with primary latent syphilis.

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备注/Memo

备注/Memo:
[基金项目] 遵义医学院研究生创新课题(CX201314)
更新日期/Last Update: 2015-03-25