[1]刘磊,张晓彬,李振鲁.白芍总苷联合维A酸和糠酸莫米松治疗寻常性银屑病36例临床观察[J].中国皮肤性病学杂志,2014,(10):1097-1098.[doi:10.13735/j.cjdv.1001-7089.2014.1097]
 LIU Lei,ZHANG Xiao-bin,LI Zhen-lu.Clinical Observation on Total Glucosides Paeony (TGP) in Combined with Tretinoin and Momestasone Furoate on Treatment of 36 Cases with Psoriasis Vulgaris[J].The Chinese Journal of Dermatovenereology,2014,(10):1097-1098.[doi:10.13735/j.cjdv.1001-7089.2014.1097]
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白芍总苷联合维A酸和糠酸莫米松治疗寻常性银屑病36例临床观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2014年10期
页码:
1097-1098
栏目:
药物与临床
出版日期:
2014-10-20

文章信息/Info

Title:
Clinical Observation on Total Glucosides Paeony (TGP) in Combined with Tretinoin and Momestasone Furoate on Treatment of 36 Cases with Psoriasis Vulgaris
作者:
刘磊1张晓彬1李振鲁2
1.河南省信阳职业技术学院附属医院皮肤科,河南 信阳 46400;2.河南省人民医院皮肤科,河南 郑州 450003
Author(s):
LIU Lei1ZHANG Xiao-bin1LI Zhen-lu2
1.Department of Dermatology,Xinyang Vocation and Technical College,Xinyang 464000,China;2.Henan Provincial Peoples Hospital of Dermatology,Zhengzhou 450003,China
关键词:
白芍总苷维A酸糠酸莫米松银屑病寻常性
Keywords:
Total glucosides of paeon Tretinoin cream Momestasone furate creamPsoriasis vlgaris
分类号:
758.63
DOI:
10.13735/j.cjdv.1001-7089.2014.1097
文献标志码:
B
摘要:
目的观察白芍总苷联合维A酸和糠酸莫米松软膏治疗寻常性银屑病的临床疗效和安全性。 方法将入选的106例寻常性银屑病患者随机分为3组,A组(38例)予口服白芍总苷600mg(3次/d),B组(32例)予外用维A酸和糠酸莫米松软膏,C组(36例)予口服白芍总苷联合维A酸和糠酸莫米松软膏外用治疗。3组患者疗程均为6周。 结果治疗结束后,三组患者的PASI评分均低于治疗前,且C组PASI评分明显低于A组和B组,C组有效率(83.33%)明显高于A组(57.89%)和B组(53.12%),A组(13.64%)和C组(10%)复发率均低于B组(23.53%),以上差异均有统计学意义(P均<0.05)。 结论白芍总苷联合维A酸和糠酸莫米松软膏外用治疗寻常性银屑病的疗效优于单独口服白芍总苷或外用维A酸和糠酸莫米松软膏组,且白芍总苷能降低寻常性银屑病的复发率。
Abstract:
Objective To observe the clinical effect and security of total glucosides of paeony(TGP) combined with tretinoin cream and momestasone furate cream on psoriasis vulgaris(PV). Methods One hundred and six patients with PV were randomly divided into 3 groups.Group A(38 cases) were treated with TGP 600mg(three times daily).Group B(32 cases) were treated with 0.1% tretinoin cream and 0.1% momestasone furoate cream.Group C(36 cases) were treated with TGP,0.1% tretinoin cream and 0.1% momestasone furoate cream.The treatment course was 6 weeks. Results After 6-week treatment,the PASI scores in 3 groups were significantly lower than that before.The scores in group C were significantly lower than that in groups A and B.The clinical efficacy rate in group C were significantly higher than that in groups A and B (83.33% for group C vs.57.89% for group A and 53.12% for group B).The recurrence rates in group B were significantly higher than that in groups A and C (23.53% for group B vs.13.64% for group A and 10% for group C).They were all signaficantly different(all P<0.05). Conclusion The combination of TGP with 0.1% tretinoin cream and 0.1% momestasone furoate cream is more effective than that in TGP alone or the combination of 0.1% tretinoin cream and 0.1% momestasone furoate cream for PV.TGP can reduce recurrence.

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备注/Memo

备注/Memo:
[通讯作者]李振鲁,E-mail 1419480293@qq.com
更新日期/Last Update: 2014-10-20