[1]张旭焱,李雪,牟妍,等.乳腺癌术后局部出现Paget病1例[J].中国皮肤性病学杂志,2014,(10):1055-1057.[doi:10.13735/j.cjdv.1001-7089.2014.1055]
 ZHANG Xu-yan,LI Xue,MOU Yan,et al.A Case of Paget’s Disease of Local Occurance after Breast Cancer Operation[J].The Chinese Journal of Dermatovenereology,2014,(10):1055-1057.[doi:10.13735/j.cjdv.1001-7089.2014.1055]
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乳腺癌术后局部出现Paget病1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2014年10期
页码:
1055-1057
栏目:
病例报告
出版日期:
2014-10-20

文章信息/Info

Title:
A Case of Paget’s Disease of Local Occurance after Breast Cancer Operation
作者:
张旭焱12李雪1牟妍1常莉1王一宇1于凯1赵桓玉1朱文静1夏建新1
1.吉林大学第二医院皮肤科,吉林 长春 130041;2.内蒙古兴安盟乌兰浩特市蒙医院皮肤科,内蒙古 乌兰浩特137400
Author(s):
ZHANG Xu-yan12LI Xue1MOU Yan1CHANG Li1WANG Yi-yu1YU Kai1ZHAO Huan-yu1ZHU Wen-jing1XIA Jian-xin1
1.Department of Dermatology,the Second Hospital of Jilin University,Changchun 130041,China;2.Department of Dermatology,Inner Mongolia Xingan Meng Ulanhot Mongolia Hospital,Ulanhot 137400,China
关键词:
乳腺癌术后Paget病
Keywords:
Post-operation of mastocarcinomaPaget’s disease
分类号:
R739.5
DOI:
10.13735/j.cjdv.1001-7089.2014.1055
文献标志码:
B
摘要:
患者女,60岁。3年前行左侧乳腺癌改良根治术,术后病理报告为浸润性导管癌。近20d来左侧胸壁皮肤出现粟粒大小丘疹及结节,伴破溃、结痂。组织病理示:表皮全层见肿瘤细胞浸润,此肿瘤细胞体积较大,胞质呈空泡状,核较大、深染,异型性明显,符合Paget病。免疫组织化学示:肿瘤细胞CEA阳性,CK7阳性,Her-2阳性,ER和PR均阴性,S100蛋白阴性,60%肿瘤细胞Ki67阳性,此结果与该患乳腺癌的免疫组织化学结果相同。诊断:乳癌切除术后,胸壁Paget病。
Abstract:
A 60-year-old women presented with local papules,nodules and crust for 20 days.The patient received modified radical mastectomy of left breast cancer at the local hospital 3 years ago.The pathological results was invasive ductal carcinoma.About 20 days ago,millet-sized papules and nodules were found on the left chest wall,and the lesions were gradually increased and evolved into ulceration and incrustation.Histopathologic examination revealed infiltration of tumor cells in the whole epidermis.The tumor cells were large,round,clear-stained cells with large nulei and obvious atypia,which were compatible with the diagnosis of Paget’s disease.Immunohistochemically,tumor cells were positive for CEA ,CK7 and Her-2,60 percent positive for Ki67,but negative for ER,PR and S100,which was in accordance with immunohistochemical result of the breast cancer.The diagnosis was made as post-operation of mastocarcinoma,Paget’s disease of chest wall.

参考文献/References:


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备注/Memo

备注/Memo:
[通讯作者]夏建新,E-mail:jianxinxia2003@tom.com
更新日期/Last Update: 2014-10-20