[1]张旭焱,李雪,牟妍,等.乳腺癌术后局部出现Paget病1例[J].中国皮肤性病学杂志,2014,(10):1055-1057.[doi:10.13735/j.cjdv.1001-7089.2014.1055]
　ZHANG Xu-yan,LI Xue,MOU Yan,et al.A Case of Paget’s Disease of Local Occurance after Breast Cancer Operation[J].The Chinese Journal of Dermatovenereology,2014,(10):1055-1057.[doi:10.13735/j.cjdv.1001-7089.2014.1055]
点击复制

乳腺癌术后局部出现Paget病1例
分享到：

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2014年10期
页码:
1055-1057
栏目:
病例报告
出版日期:
2014-10-20

文章信息/Info

Title:
A Case of Paget’s Disease of Local Occurance after Breast Cancer Operation
作者:
张旭焱1; 2; 李雪1; 牟妍1; 常莉1; 王一宇1; 于凯1; 赵桓玉1; 朱文静1; 夏建新1
1.吉林大学第二医院皮肤科，吉林 长春 130041；2.内蒙古兴安盟乌兰浩特市蒙医院皮肤科，内蒙古 乌兰浩特137400
Author(s):
ZHANG Xu-yan1; 2; LI Xue1; MOU Yan1; CHANG Li1; WANG Yi-yu1; YU Kai1; ZHAO Huan-yu1; ZHU Wen-jing1; XIA Jian-xin1
1.Department of Dermatology，the Second Hospital of Jilin University，Changchun 130041，China；2.Department of Dermatology，Inner Mongolia Xingan Meng Ulanhot Mongolia Hospital，Ulanhot 137400，China
关键词:
乳腺癌术后; Paget病
Keywords:
Post-operation of mastocarcinoma; Paget’s disease
分类号:
R739.5
DOI:
10.13735/j.cjdv.1001-7089.2014.1055
文献标志码:
B
摘要:
患者女，60岁。3年前行左侧乳腺癌改良根治术，术后病理报告为浸润性导管癌。近20d来左侧胸壁皮肤出现粟粒大小丘疹及结节，伴破溃、结痂。组织病理示：表皮全层见肿瘤细胞浸润，此肿瘤细胞体积较大，胞质呈空泡状，核较大、深染，异型性明显，符合Paget病。免疫组织化学示：肿瘤细胞CEA阳性，CK7阳性，Her-2阳性，ER和PR均阴性，S100蛋白阴性，60%肿瘤细胞Ki67阳性，此结果与该患乳腺癌的免疫组织化学结果相同。诊断：乳癌切除术后，胸壁Paget病。
Abstract:
A 60-year-old women presented with local papules，nodules and crust for 20 days.The patient received modified radical mastectomy of left breast cancer at the local hospital 3 years ago.The pathological results was invasive ductal carcinoma.About 20 days ago，millet-sized papules and nodules were found on the left chest wall，and the lesions were gradually increased and evolved into ulceration and incrustation.Histopathologic examination revealed infiltration of tumor cells in the whole epidermis.The tumor cells were large，round，clear-stained cells with large nulei and obvious atypia，which were compatible with the diagnosis of Paget’s disease.Immunohistochemically，tumor cells were positive for CEA ，CK7 and Her-2，60 percent positive for Ki67，but negative for ER，PR and S100，which was in accordance with immunohistochemical result of the breast cancer.The diagnosis was made as post-operation of mastocarcinoma，Paget’s disease of chest wall.

参考文献/References:


[1] 赵辨.中国临床皮肤病学［M］.南京：江苏科学技术出版社，2010：1521-1522.
[2] 余永，赵志勇.乳腺Paget病一例分析［J］.临床误诊误治，2010，23（5）:39.
[3] Fu W，Mittel VK，Young SC，et al.Paget disease of the breast: analysis of 41 patients［J］.Am J Clin Oncol，2001，24（4）：397-400.
[4] Dalberg K，Hellborg H，Warnberg F.Paget’s disease of the nipple in a population based cohort［J］.Breast Cancer Res Treat，2008，111(2):313-319.
[5] Chen CY，Sun LM，Anderson BO.Paget disease of the breast: changing patterns of incidence，clinical presentation，and treatment in the U.S.［J］.Cancer，2006，107(7):1448-1458.
[6] Marucci G，Betts CM，Golouh R，et al.Toker cells are probably precursors of Paget cell carcinoma: a morphological and ultrastructural description［J］.Virchows Arch，2002，441(2):117-123.

相似文献/References:

[1]陈宇,花志祥,李隽,等.PTEN和Ki67在乳房外Paget病中的表达[J].中国皮肤性病学杂志,2015,(10):1017.[doi:10.13735/j.cjdv.1001.7089.201407124]
　CHEN Yu,HUA Zhi xiang,LI Juan,et al.Expression of PTEN and Ki67 in Extramammary Paget’s Disease[J].The Chinese Journal of Dermatovenereology,2015,(10):1017.[doi:10.13735/j.cjdv.1001.7089.201407124]
[2]陈宇,花志祥,李隽,等.乳房外Paget病皮损中P27和细胞周期蛋白E表达[J].中国皮肤性病学杂志,2015,(11):1127.[doi:10.13735/j.cjdv.1001-7089.201408052]
　CHEN Yu,HUA Zhi xiang,LI Jun,et al.Expression and Significance of P27 and CyclinE in Extramammary Paget’s Disease[J].The Chinese Journal of Dermatovenereology,2015,(10):1127.[doi:10.13735/j.cjdv.1001-7089.201408052]
[3]叶振源,涂云华,薛月萃,等.乳房外Paget病误诊为湿疹1例[J].中国皮肤性病学杂志,2016,(04):422.[doi:10.13735/j.cjdv.1001-7089.201501049]
　YE Zhen yuan,TU Yun hua,XUE Yue cui,et al.A Case report of Misdiagnosis of Extramammary Paget's Disease[J].The Chinese Journal of Dermatovenereology,2016,(10):422.[doi:10.13735/j.cjdv.1001-7089.201501049]
[4]罗婉仪,何彩凤,季必华.乳房外Paget病3例[J].中国皮肤性病学杂志,2017,(09):1036.[doi:10.13735/j.cjdv.1001-7089.201702018]
　LUO Wan-yi,HE Cai-feng,JI Bi-hua.Three Cases of Extramammary Paget's Disease LUO Wan-yi,HE Cai-feng,JI Bi-hua[J].The Chinese Journal of Dermatovenereology,2017,(10):1036.[doi:10.13735/j.cjdv.1001-7089.201702018]
[5]单滢,王飞.腋窝乳房外Paget病1例[J].中国皮肤性病学杂志,2013,(02):181.
[6]朱瑞政,严建娜,沈娟,等.原发性乳房外Paget病43例临床病理分析[J].中国皮肤性病学杂志,2020,(11):1277.[doi:10.13735/j.cjdv.1001-7089.202003232]
　ZHU Ruizheng,YAN Jianna,SHEN Juan,et al.Clinical and Histopathological Analysis of 43 Patients with Primary Extramammary Paget's Disease[J].The Chinese Journal of Dermatovenereology,2020,(10):1277.[doi:10.13735/j.cjdv.1001-7089.202003232]

备注/Memo

备注/Memo:
［通讯作者］夏建新，E-mail:jianxinxia2003@tom.com
更新日期/Last Update: 2014-10-20