[1]李咏梅.新生儿红斑狼疮18例临床分析[J].中国皮肤性病学杂志,2014,(05):476-479.[doi:10.13735/j.cjdv.10017089.2014.0476]
 LI Yongmei.Neonatal Lupus Erythematosus: Clinical Analysis of 18 Cases[J].The Chinese Journal of Dermatovenereology,2014,(05):476-479.[doi:10.13735/j.cjdv.10017089.2014.0476]
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新生儿红斑狼疮18例临床分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2014年05期
页码:
476-479
栏目:
临床经验
出版日期:
2014-05-20

文章信息/Info

Title:
Neonatal Lupus Erythematosus: Clinical Analysis of 18 Cases
作者:
李咏梅
重庆医科大学儿童医院皮肤科,重庆 400014
Author(s):
LI Yongmei
Department of Dermatology, Children’s Hospital of Chongqing Medical University,Chongqing 400014, China
关键词:
红斑狼疮新生儿抗Ro/SSA抗体抗La/SSB抗体
Keywords:
Lupus erythematosus Neonatal AntiRo/SSA AntiLa/SSB
分类号:
R 593.24
DOI:
10.13735/j.cjdv.10017089.2014.0476
文献标志码:
B
摘要:
目的总结新生儿红斑狼疮的临床特点。方法[HTK]记录并分析我科6年来诊治的18例新生儿红斑狼疮患儿的临床资料,探索发病时间与皮疹及抗体消退时间的关系。结果[HTK]18例新生儿红斑狼疮,男10例,女8例,平均发病日龄308d(0~75d),30d以内发病9例,30d以后发病9例。所有患儿头皮、面部均有亚急性皮肤型红斑狼疮样皮损,部分患儿皮损累及躯干、四肢或全身泛发。所有患儿及母亲均有抗Ro/SSA抗体和(或)抗La/SSB抗体阳性。6例患儿轻度贫血,2例患儿高胆红素血症。18例患儿心电图检查均无房室传导阻滞。随访发现患儿皮损和自身抗体均在1年内消失,皮疹、抗体消退时间与发病早晚无关,抗体通常晚于皮疹1~2个月消退。1例母亲2年后发生系统性红斑狼疮。结论[HTK]新生儿红斑狼疮有自限性,预后良好,仍需长期随访。建议将自身抗体和胎儿超声纳入产前检查,以提高新生儿红斑狼疮诊断率和降低新生儿红斑狼疮房室传导阻滞发生率。
Abstract:
Objective To summarize the clinical characteristics of neonatal lupus erythematosusMethodsThe clinical data of 18 cases of neonatal lupus erythematosus diagnosed and treated in the past 6 years in our department were recorded and analyzed on the time of onset, subsided of rash and antibodies’ regression timeResultsThere were 18 infants with neonatal lupus erythematosus, including 10 males and 8 femalesThe average age of onset was 308 days (0~75d), of which nine cases occurred in less than 30 days, nine occurred within 30~90 daysAll infants had skin lesions resembling subacute cutaneouse lupus erythematosus on the scalp and faceSome infants also had rash involving the trunk, limbs or generalized systemicAntiRo/SSA and(or) AntiLa/SSB antibodies were found in the sera of the 18 infants and their mothersSix infants had mild anemia, two cases had hyperbilirubinemiaElectrocardiogram revealed no congenital heart blockThe rash and autoantibodies (AntiRo/SSA and AntiLa/SSB) of the 18 infants disappeared completely after followup of a yearThe rash subsided time and the antibodies’ regression time had no correlations with the time of onsetAntibodies usually vanished 1~2 months later than the rashOne baby’s mother occurred systemic lupus erythematosus two years laterConclusionNeonatal lupus erythematosus is usually benign and selflimited but need longterm followupWe suggest that autoantibodies and fetal ultrasonography be included in prenatal examination, in order to improve the diagnosis rates of neonatal lupus erythematosus and reduce neonatal incidence of atrioventricular block

参考文献/References:


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更新日期/Last Update: 2014-05-20