[1]朱凤,朱黎明,李英,等.大黄蟅虫胶囊治疗血瘀型银屑病30例临床观察[J].中国皮肤性病学杂志,2014,(02):195-196.
 ZHU Feng,ZHU Liming,LI Ying,et al.Clinical Observation on 30 Cases with Blood Stasis Type Psoriasis Dahuang Zhechong Capsule[J].The Chinese Journal of Dermatovenereology,2014,(02):195-196.
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大黄蟅虫胶囊治疗血瘀型银屑病30例临床观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2014年02期
页码:
195-196
栏目:
中医中药
出版日期:
2014-02-20

文章信息/Info

Title:
Clinical Observation on 30 Cases with Blood Stasis Type Psoriasis Dahuang Zhechong Capsule
作者:
朱凤朱黎明李英栾立云陈兰
江苏省中西医结合医院皮肤科,江苏 南京 210028
Author(s):
ZHU FengZHU LimingLI YingLUAN LiyunCHEN Lan
Department of Dermatology,Jiangsu Provincial Hospital of Integrated Chinese Traditional and Western Medicine,Nanjing 210028,China
关键词:
银屑病寻常性血瘀型大黄蟅虫胶囊
Keywords:
Psoriasisvulgaris Blood stasis type Dahuang Zhechong capsule
分类号:
R 758.63
文献标志码:
B
摘要:
目的 观察大黄蟅虫胶囊治疗血瘀型银屑病的临床疗效。 方法 将入选的60例寻常性(血瘀型)银屑病患者随机分成两组,各30例,治疗组予大黄蟅虫胶囊口服,对照组予阿维A胶囊口服,两组均同时予维生素E乳膏外涂,疗程12周,随访6个月。 结果 治疗组治疗前PASI积分为(18.73±4.15)分,治疗后第4,8和12周时依次为(16.70±3.33)分,(10.37±2.37)分和(2.96±3.48)分;对照组依次为(18.65±3.19)分,(16.12±2.34)分,(10.07±2.13)分和(5.66±4.53)分。治疗组和对照组治疗后组内的PASI积分均比治疗前明显降低( P 均<0.01)。治疗第4周时两组患者评分差异无统计学意义( P >0.05);治疗8周和12周时两组间评分差异均有统计学意义( P 均<0.05)。治疗结束时治疗组有效率为93.33%,对照组为96.67%,差异无统计学意义( P >0.05)。治疗组复发率(2例,13.33%)明显低于对照组(8例,72.73%)。 结论 大黄蟅虫胶囊治疗血瘀型银屑病效果明显,其作用机制可能在于其“活血通络、攻逐瘀血”抗血栓的机理。
Abstract:
Objective To observe the Dahuang Zhechong capsule clinical curative effect for the treatment of blood stasis type of psoriasis. Methods The 60 cases of vulgaris psoriatic(blood stasis type) patients were randomly divided into two groups,the treatment group was given to Dahuang Zhechong capsule oral and control group to avi A capsule orally.Both groups were coated with vitamin E cream,after 12 weeks of treatment,were followed up for 6 months. Results The treatment group PASI score was(18.73±4.15) points before treatment,4,8 and 12 weeks after treatment,in turn,was(16.70±3.33) ,(10.37±2.37) and(2.96 ±3.48) ; the control group,in turn,was(18.65±3.19) and(16.12±2.34) ,(10.07±2.13) and(5.66±4.53) .The treatment group and control group in the PASI score after treatment group were significantly lower than that of before treatment( P <0.01).After 4 weeks, when there was no statistically significant difference scores between two groups( P >0.05); After treatment of 8 and 12 weeks score differences between the two groups had statistical significance( P <0.05).The treatment group effective rate was 93.33% at the end of the treatment,control group was 96.67%,there was no statistically significant difference( P >0.05).Recurrence rate(2 cases,13.33%) treatment group was obviously lower than the control group(8 cases,72.73%). Conclusion The Dahuang Zhehong capsules effect is obvious,for treating psoriasis stasis and its mechanism may be in its “Huoxuetongluo attack by stasis” antithrombotic mechanism.

参考文献/References:


[1] 赵辨.临床皮肤病学[M].江苏:江苏科学技术出版社,2001:759-772.
[2] 刘丽芳,贺菊乔.实用临床皮肤诊疗手册[M].太原:山西科学技术出版社,2007:234-266.
[3] 顾有守.中、重度银屑病的联合治疗[J].临床皮肤科杂志,2005,34(3):196-198.
[4] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:299-301.
[5] 刘久波,范金波,黄平,等.银屑病患者微循环与血液流变性变化[J].微循环杂志,2008,18(3):42-44.
[6] 郭伟光,姜德友.大黄蛰虫丸对大鼠静脉血栓形成模型ET,6ketoPGF1α的影响[J].中医药信息,2009,26(4):47-48.

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更新日期/Last Update: 2014-02-20