[1]陈慧君,陈治国.白芍总苷胶囊治疗前、后寻常性银屑病患者外周血IL-17,TNF-α和IFN-γ的变化[J].中国皮肤性病学杂志,2014,(02):135-137.
 CHEN Huijun,CHEN Zhiguo.The Levels of IL17,TNFα,IFNγ in the Serum in Patients with Psoriasis Vulgaris Before and After TGP Treatment[J].The Chinese Journal of Dermatovenereology,2014,(02):135-137.
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白芍总苷胶囊治疗前、后寻常性银屑病患者外周血IL-17,TNF-α和IFN-γ的变化
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2014年02期
页码:
135-137
栏目:
论著
出版日期:
2014-02-20

文章信息/Info

Title:
The Levels of IL17,TNFα,IFNγ in the Serum in Patients with Psoriasis Vulgaris Before and After TGP Treatment
作者:
陈慧君陈治国
承德市中心医院皮肤科,河北 承德067000
Author(s):
CHEN HuijunCHEN Zhiguo
(Department of Dermatology,Centrial Hoepital of Chende,Chengde 067000,China)
关键词:
白芍总苷银屑病寻常性白介素17肿瘤坏死因子α干扰素γ
Keywords:
TGP Psoriasis vulgaris IL-17 TNF-α IFN-γ
分类号:
R 758.63
文献标志码:
A
摘要:
目的 检测白芍总苷(TGP)治疗寻常性银屑病(PV)前、后患者外周血中IL-17,TNF-α,IFN-γ的水平,进一步了解TGP在银屑病治疗中的作用机制。 方法 应用酶联免疫吸附试验(ELISA)检测30例PV患者TGP治疗前、后外周血中IL-17,TNF-α,IFN-γ的水平,并与20例健康对照者比较,分析这几种细胞因子在治疗前、后与PASI评分的相关性。 结果 治疗前IL-17,TNF-α,IFN-γ水平均明显高于 健康对照组,差异有统计学意义( P <0.01),治疗后仍高于健康对照组,但较治疗前明显下降( P <0.05)。且PASI评分与血清中IL-17,TNF-α,IFN-γ表达呈正相关( P <0.05)。 结论 TGP可能具有调节 Th17相关细胞因子(IL-17)和Th1型细胞因子(TNF-α ,IFN-γ)水平的作用,从而达到治疗银屑病的作用。
Abstract:
Objective To investigatie the effects of total glucosides of paeony(TGP) on levels of IL-17,TNF-α,IFN-γ in the serum of patients with psoriasis vulgaris(PV),to analyze its therapeuticmechanisms. Methods Enzyme linked immunosorbent assay(ELISA) was used to dected the level of IL-17,TNF-α,IFN-γ in serum of patients with PV and health controls and their correlations with PASI score was analyzed before and after treatment. Results Patients with PV had increased levels of IL-17,TNF-α,IFN-γ which compared with health control group( P <0.01); after the treatment,the levels of IL-17,TNF-α,IFN-γ were significantly reduced( P <0.05); serum concentrations of IL-17,TNF-α,IFN-γ showed significant positive correlations with PASI score. Conclusion TGP may rectify Th17 cellrelated cytokines(IL-17)and thelper1 cellrelated cytokines(TNF-α,IFN-γ) to play a role intreating psoriasis.

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更新日期/Last Update: 2014-02-20