[1]白玉,李福秋,季永智,等.表皮松解性角化过度鱼鳞病合并肾母细胞癌1例[J].中国皮肤性病学杂志,2014,(01):79-80.
 BAI Yu,LI Fu-qiu,JI Yong-zhi,et al.A Case of Epidermolytic Hyperkeratosis Ichthyosis with Whilms Tumor[J].The Chinese Journal of Dermatovenereology,2014,(01):79-80.
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表皮松解性角化过度鱼鳞病合并肾母细胞癌1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2014年01期
页码:
79-80
栏目:
病例报告
出版日期:
2014-01-20

文章信息/Info

Title:
A Case of Epidermolytic Hyperkeratosis Ichthyosis with Whilms Tumor
作者:
白玉李福秋季永智齐琳毕云斐
吉林大学第二医院皮肤科, 吉林 长春 130000
Author(s):
BAI Yu LI Fu-qiu JI Yong-zhi QI Lin BI Yun-fei
(Department of Dermatology, the Second Hospital of Jilin University, Changchun 130041, China)
关键词:
鱼鳞病 表皮松解 角化过度 肾母细胞癌
Keywords:
Ichthyosis Epidermolytic Hyperkeratosis Wilms'tumor
分类号:
R 758.5*2; R 737.11
文献标志码:
B
摘要:
患儿男,14岁。全身红斑、水疱、鳞屑14年,2年前本院肾穿刺诊断为肾母细胞癌。皮损组织病理示:表皮明显增厚,可见粗大的透明角质颗粒,棘层明显增厚,棘层上部及颗粒层可见细胞核周空泡样变,界不清,真皮浅层炎性细胞浸润。诊断:表皮松解性角化过度鱼鳞病; 肾母细胞癌。
Abstract:
A 14-year old boy presented with erythema, blister, scale for 14 years was diagnosed as Wilms'tumor about 2 years ago.Histopathology showed epidermal thickening, oversize keratohyalin granule, perinuclear vacuolation of upper part of stratum spinosum and stratum granulosum and inflammatory cell infiltration in the upper dermis.Diagnose:epidermolytic hyperkratosis ichthyosis.

参考文献/References:


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[3] Cuevas-C ovarrubias SA,Jiménez-Vaca AL,González-Huerta LM,et al.Somatic and germinal mosaicism for the steroid sulf atase gene deletion in a steroid sul fat as deficiency carrier[J].J In vest Dermatol,2002,119(4):972-975.
[4] 孙秀坤,关欣,朱学骏.Siemens大疱性鱼鳞病基因突变国内首次报道[J].临床皮肤科杂志,2002,31(10):610-611.
[5] 沈菲,梅小斌.鱼鳞病伴发的肾脏病[J].药学服务与研究,2011,11(3):227-229.
[6] Becker K,Csiks M,Srdy M,et al.Identification of two novel nonsense mutations in the transglutaminase 1 gene in a Hungarian patient with congenital ichthyosi form erythroderma[J].Exp Dermatol,2003,12(3):324-329.
[7] Akil I,Ozguven A,Canda E,et al.Co-existence of chronic renal failure,renal clear cell carcinoma,and Blau syndrome[J].Pediatr Nephrol,2010,25(5):977-981.
[8] Levy O,Tishler M.Acquired ichthyosis as the primary manifestation of renal cell carcinoma[J].Isr Med Assoc J,2009,11(2):121-122.

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备注/Memo

备注/Memo:
[作者单位] 吉林大学第二医院皮肤科, 吉林 长春 130000 [通讯作者] 李福秋,E-mail:lifuqiu@medmail.com
更新日期/Last Update: 2014-01-20