[1]沈小雁,李可嘉,曹华,等.皮肌炎并发结外NK/T细胞淋巴瘤1例[J].中国皮肤性病学杂志,2013,(08):815-816+818.
 SHEN Xiao-yan,LI Ke-jia,CAO Hua,et al.A Case of Extranodal NK/T Cell Lymphoma with Dermatomyositis[J].The Chinese Journal of Dermatovenereology,2013,(08):815-816+818.
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皮肌炎并发结外NK/T细胞淋巴瘤1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2013年08期
页码:
815-816+818
栏目:
病例报告
出版日期:
2013-08-20

文章信息/Info

Title:
A Case of Extranodal NK/T Cell Lymphoma with Dermatomyositis
文章编号:
1001-7089(2013)08-0815-02
作者:
沈小雁李可嘉曹华徐涵郑捷
上海交通大学医学院附属瑞金医院皮肤科,瑞金-耶鲁皮肤淋巴瘤治疗中心,上海 200025
Author(s):
SHEN Xiao-yan LI Ke-jia CAO Hua XU Han ZHENG Jie
Department of Dermatology, Ruijin-Yale Cutaneous Lymphoma Ttreatment Center, Ruijin Hospital, Medical School of Shanghai Jiaotong University, Shanghai 200025, China
关键词:
结外NK/T细胞淋巴瘤 皮肌炎
Keywords:
Extranodal NK/T-cell lymphoma Dermatomyositis
分类号:
R 739.5
文献标志码:
B
摘要:
患者女,56岁。4年前小腿出现红斑并发皮下结节,1年前出现面部肿胀、四肢肌肉酸痛,伴LDH(659IU/L)、GOT(165IU/L)、CPK(551IU/L)升高。皮损组织病理示:基底细胞液化变性,真皮和皮下脂肪内较多淋巴样细胞浸润,有异形,部分围绕血管,管壁有破坏。免疫组化示:CD3(-),CD2(+),CD4(-/+),CD8(-/+),CD30(-/+),CD56(+),TIA(+),GranzymeB(+),Perforin(+)。肌肉活检见少量肌纤维肿胀,肌横纹不清,肌核增多,肌束间少量淋巴细胞浸润。肺HRCT示肺间质性改变。诊断:结外NK/T细胞淋巴瘤; 皮肌炎。皮肌炎并发皮肤T细胞淋巴瘤报道少见。皮肌炎的皮下结节有并发结外NK/T细胞淋巴瘤的可能,应进行组织病理检查予以排除。
Abstract:
A 56-year-old female presented with repeated erythema, subcutaneous nodules on the legs for four years. She had been suffering from face swelling, muscle soreness for one year, accompany with elevation of LDH, GOT, CPK. The histopathology of the cutaneous lesion represented basal cells liquefied degeneration and infiltration of heterotypic lymphoidocytes within the dermal and subcutaneous adipose layer. Blood vessels were destroyed and surrounded with heterotypic lymphocytes. Immunohistochemical staining showed CD3-, CD2+, CD4-/+, CD8-/+, CD30-/+, CD56+, TIA+, GranzymeB+ and Perforin+. Histopathologic findings of the muscle biopsy represented muscle fiber swelling, muscle stripes indistinct, myonuclear increase and perifascicular infiltrated with small amount of lymphocytes. High-resolution CT(HRCT)scanning displayed interstitial lung disease. The diagnosis of extranodal NK/T-cell lymphoma with dermatomyositis was made. The concomitant of dermatomyositis and cutaneous T cell lymphoma was rarely reported. The lesion of nodules of patient with dermatomyositis highlights the need of skin biopsy to exclude the possibility of extranodal NK/T-cell lymphoma.

参考文献/References:

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备注/Memo

备注/Memo:
[通讯作者]郑捷, E-mail:jie-zheng2001@126.com
更新日期/Last Update: 2013-08-20