[1]董文斌,赵金仙,李世福,等.未抗病毒治疗的HIV/AIDS患者 CD4+T淋巴细胞快速下降和显著下降比例及相关因素[J].中国皮肤性病学杂志,2018,(05):529-535.[doi:10.13735/j.cjdv.1001-7089.201709030]
　DONG Wenbin,ZHAO Jinxian,LI Shifu,et al.Proportion of Rapid and Significant Decline of CD4+T Cell Counts Among Antiretroviral Treatment-naive HIV/AIDS Patients and Related Influencing Factors[J].The Chinese Journal of Dermatovenereology,2018,(05):529-535.[doi:10.13735/j.cjdv.1001-7089.201709030]
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未抗病毒治疗的HIV/AIDS患者 CD4+T淋巴细胞快速下降和显著下降比例及相关因素
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年05期
页码:
529-535
栏目:
性传播疾病
出版日期:
2018-05-01

文章信息/Info

Title:
Proportion of Rapid and Significant Decline of CD4+T Cell Counts Among Antiretroviral Treatment-naive HIV/AIDS Patients and Related Influencing Factors
作者:
董文斌; 赵金仙; 李世福; 陈黎跃; 蔡英; 许杰; 鲁建波; 李顺祥
云南省玉溪市疾病预防控制中心,云南 玉溪 653100
Author(s):
DONG Wenbin;  ZHAO Jinxian;  LI Shifu;  CHEN Liyue;  CAI Ying;  XU Jie;  LU Jianbo; LI Shunxiang
Yuxi Centre for Disease Control and Prevention, Yuxi 653100, China
关键词:
HIV;  CD4+T淋巴细胞;  快速下降;  显著下降;  影响因素
Keywords:
HIV;  CD4+T lymphocyte;  Rapid decline;  Significant decline;  Influential factors
分类号:
R 512.91
DOI:
10.13735/j.cjdv.1001-7089.201709030
文献标志码:
B
摘要:
目的 探讨云南省玉溪市新报告的艾滋病病毒(HIV)感染者/艾滋病(AIDS)患者(简称HIV/AIDS)在未抗病毒治疗的情况下其CD4+T值快速下降及显著下降情况,分析其相关因素。 方法 收集未抗病毒治疗HIV/AIDS历次CD4+T淋巴细胞计数值、人口学特征、样本来源和可能感染途径等,计算快速下降率和显著下降率并分析相关因素。结果 1 480例HIV/AIDS其CD4+T值快速下降率和显著下降率分别为42.64%(631/1 480)、52.23%(773/1 480),单因素分析结果显示,CD4+T值快速下降与性别、文化、年龄、职业、婚姻状况、传播途径、首次CD4+T值以及首末次检测时间间隔有关,CD4+T值显著下降与文化、民族、传播途径、首次CD4+T值以及首末次检测时间间隔有关; 经多因素Logistic回归分析表明,女性(OR=1.271,95%CI: 1.044～1.674)、已婚(OR=1.460,95%CI:1.093～1.949)、传播途径注射吸毒(OR=1.365,95%CI:1.016～1.833)、首次CD4+T值> 500 cell/μL,更容易出现CD4+T值快速下降,首末次检测时间间隔> 18个月更不容易出现CD4+T值快速下降; 传播途径注射吸毒(OR=1.286,95%CI:1.018～1.625)、首次CD4+T值> 500 cell/μL、首末次检测时间间隔≥ 6个月,更容易出现CD4+T值显著下降,传播途径为男男性行为(OR=0.426,95%CI:0.199～0.914)更不容易出现CD4+T值显著下降。 结论 HIV/AIDS患者CD4+T值快速下降和显著下降与性别、婚姻状况、传播途径等因素有关,需加强对女性、已婚、注射吸毒人群的定期随访,及时启动抗病毒治疗。
Abstract:
Objective To examine the proportion of rapid and significant decline of CD4+T cell counts and related influencing factors among antiretroviral treatment(ART)-naive HIV/AIDS patients newly reported in Yuxi, Yunnan. Methods The information of ART-naive HIV/AIDS patients including all previous CD4+T cell counts, demographic characteristics, sample source and potential route of HIV transmission were collected, and the rates of rapid and significant CD4+T decline were counted, and the related factors were statistically analyzed. Results The rates of rapid and significant CD4+T decline were 42.64%(631/1 480)and 52.23%(773/1 480)respectively. Univariate logistic regression analyses indicated that rapid decline of CD4+T cell counts were associated with gender, education, age, occupation, marital status, route of HIV infection, baseline CD4+T cell counts, and interval between first and last CD4+T testing, whereas the significant decline of CD4+T cell counts were associated with education, ethnicity, route of HIV infection, baseline CD4+T cell counts, and interval between first and last CD4+T testing. Multivariate logistic regression analyses indicated that females(OR=1.271, 95%CI: 1.044～1.674), being married(OR=1.460, 95%CI: 1.093～1.949), HIV transmitted through injected drug use(OR=1.365, 95%CI: 1.016～1.833), initial CD4+T cell counts > 500 cell/μL were more likely to lead to a rapid CD4+T decline, whereas interval between first and last CD4+T testing > 18 months was less likely to result in a rapid CD4+T decline; HIV transmitted through injected drug use(OR=1.286, 95%CI:1.018～1.625), initial CD4+T cell counts > 500 cell/μL,and interval between first and last CD4+T testing > 6 months were more likely to contribute to a significant CD4+T decline, whereas male-to-male contact(OR=0.426, 95%CI: 0.199～0.914)were less likely to witness a significant CD4+T decline. Conclusion Gender, marital status, route of HIV infection were associated with rapid decline and significant decline of CD4+T cell counts. Therefore, it is important to strengthen the regular follow-up for those being female, married, transmitted through injected drug use and to initiate ART timely.

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备注/Memo

备注/Memo:
[基金项目] 科技人才引进与培养专项(云南省中青年学术和技术带头人后备人才、云南省技术创新人才培养对象,2016HB052)
[通讯作者] 李顺祥,E-mail: 791611849@qq.com
更新日期/Last Update: 2018-05-01