[1]吕涛,夏红霞,赵孝开,等.四君子汤联合乌司他丁治疗烧伤患者的疗效及其安全性[J].中国皮肤性病学杂志,2018,(01):92-96.[doi:10.13735/j.cjdv.1001-7089.201706046]
 LV Tao,XIA Hongxia,ZHAO Xiaokai,et al.The Clinical Efficacy and Safety of Sijunzi Decoction Combined with Ulinastatin[J].The Chinese Journal of Dermatovenereology,2018,(01):92-96.[doi:10.13735/j.cjdv.1001-7089.201706046]
点击复制

四君子汤联合乌司他丁治疗烧伤患者的疗效及其安全性
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年01期
页码:
92-96
栏目:
中医中药
出版日期:
2018-01-01

文章信息/Info

Title:
The Clinical Efficacy and Safety of Sijunzi Decoction Combined with Ulinastatin
作者:
吕涛1夏红霞2赵孝开1刘冰1王磊1李彦仓1李树仁1张建1娄季鹤1
1.郑州市第一人民医院烧伤科,河南 郑州 450004; 2.武汉市第三医院,湖北 武汉 430060
Author(s):
LV Tao1 XIA Hongxia2 ZHAO Xiaokai1 LIU Bing1 WANG Lei1 LI Yancang1LI Shuren1 ZHANG Jian1 LOU Jihe1
1.Department of Burn, the First People's Hospital of Zhengzhou, Zhengzhou 450004,China; 2.The Third Hospital of Wuhan, Wuhan 430060,China
关键词:
四君子汤 乌司他丁 烧伤 血小板5-羟色胺 血小板计数 细胞因子
Keywords:
Sijunzi decoction Ulinastatin Burns Platelet 5-hydroxytryptaphane Platelet counts Cytokines
分类号:
R 644
DOI:
10.13735/j.cjdv.1001-7089.201706046
文献标志码:
B
摘要:
目的 探讨四君子汤联合乌司他丁治疗烧伤患者临床疗效及对血小板5-羟色胺水平(5-hydroxytryptaphane, 5-HT)、血小板计数和细胞因子的影响。方法 以2014年3月- 2016年3月期间,我院收治的127例因热蒸汽、热水、火焰等热力因素烧伤的患者为研究对象,用随机数字表法分为治疗组(64例)、对照组(63例)。对照组在西医常规疗法的基础上静脉滴注乌司他丁,治疗组在对照组的基础上予以四君子汤治疗,连续用药14d后对两组烧伤患者临床疗效、细胞因子、PLT计数与5-HT水平、不良反应进行比较。结果 治疗组患者总有效率为90.63%,对照组为76.19%,差异有统计学意义(P<0.05); 与治疗前比较,治疗后两组患者血清中IL-6与TNF-α明显降低,且治疗组明显低于对照组, IL-2与IL-10明显升高,且治疗组高于对照组,差异有统计学意义(P<0.05); 经治疗,两组患者PLT计数与血小板5-HT明显升高,且治疗组显著高于对照组(P<0.05); 两组不良反应比较,差异无统计学意义(P>0.05)。结论 四君子汤联合乌司他丁治疗烧伤患者疗效显著,可以明显改善患者炎症反应,稳定微循环状态,无严重不良反应发生,值得在临床上推广。
Abstract:
Objective To study the clinical efficacy of Sijunzi decoction combined with ulinastatin and effect on platelet 5-hydroxytryptaphane, platelet counts and cytokines in treatment of burns.Methods The study selected 127 cases of burns patients treated in our hospital from March 2014 to March 2016, who were divided into two groups according to the method of random number table, with 64 cases in clinical group and 63 in control group.Patients in control group were treated with the routine therapy and intravenous drip of ulinastatin, while the clinical group was given extra Sijunzi decoction on the basis of control group.Then the treatment effect, the value of platelet 5-hydroxytryptaphane, platelet counts,cytokines and adverse reactions were compared after the 14 days treatment.Results Compared with 76.19% in the control group, the total effective rate of the clinical group was 90.63%.The difference was statistically significant(P<0.05).Compared with the pre-therapy, IL-6 and TNF-α of the two groups decreased while IL-2 and IL-10 increased after the treatment(P<0.05).Compared with the control group, the value of IL-6 and TNF-α in patients of the clinical group were lower after the treatment while IL-2 and IL-10 were higher(P<0.05).Compared with the pre-therapy,value of platelet 5-hydroxytryptaphane and platelet counts of the two groups increased after the treatment.And the treatment group was significantly higher than the control group(P<0.05).The difference of the two groups of adverse reactions was not statistically significant(P>0.05).Conclusion Sijunzi decoction has better effect on burns and can significantly improve inflammatory response, and make microcirculation stable.No serious adverse reactions occurred.It is worthy of clinical promotion.

参考文献/References:

[1] 黄仲海.烧伤的中医药治疗研究进展[J].亚太传统医药,2013,9(9):48-50.
[2] 李一兵.中医治疗烧伤的研究进展[J].医学信息(上旬刊),2011,24(7):4822-4824.
[3] 曾鸿孟,王宇,唐乾利.烧伤的分子机制研究现状与进展[J].中国烧伤创疡杂志,2016,28(3):197-201.
[4] 林斌.中医辨证治疗烧伤104例[J].中国中医药现代远程教育,2016,14(17):60-62.
[5] 李春耕,丛坤.中西医结合治疗重度烧伤中期患者50例[J].山东中医杂志,2014,33(7):567-568.
[6] 王旭文,齐杰,生孟军,等.四君子汤联合乌司他丁治疗重度烧伤临床研究[J].中医学报,2017,32(1):135-138.
[7] 童庭辉,工春艳,赖麒,等.加味四君子汤对烧伤患者血清清蛋白和前清蛋白的影响[J].重庆医学,2012,41(5):449-450.
[8] 熊爱兵,赖麒.加味四君子汤对严重烧伤患者免疫功能的影响[J].中国烧伤创疡杂志,2014,26(5):319-322.
[9] 房国荣.康复新液治疗烧伤疗效观察50例[J].中国医药指南,2012,10(10):306-307.
[10] 李华芳,林治光,王慧芳,等.自杀行为患者血小板5-HT浓度[J].伤害精神医学,2003,15(1):1-3.
[11] 邱伟,潘咏梅.桃红四物汤加减联合湿润烧伤膏外敷治疗轻中度烧伤的临床疗效观察[J].中国医药指南,2013,11(35):515-516.
[12] 冯登超,高东东,邬天刚.烧伤病人血液炎性细胞因子水平变化的研究[J].中国实验诊断学,2017,21(2):269-272.
[13] 王际刚.高压电烧伤大鼠血清5-羟色胺、儿茶酚胺的变化及乌司他丁干预作用[D].河北医科大学,2016,33-35.
[14] 潘宇红,黄璇,丁羚涛,等.严重烧伤患者促炎和抗炎细胞因子的变化及其意义[J].国际检验医学杂志,2013,34(19):2510-2511,2513.
[15] 夏正国,徐庆连,唐益忠,等.血小板计数的动态变化对危重烧伤患者病情和预后的判断价值[J].中华损伤与修复杂志(电子版),2012,7(2):156-160.
[16] 王晓红,柳明,马少林,等.血小板计数及其时相变化对危重病患者预后的预测价值[J].中国急救医学,2003,23(12):866.
[17] 朱岚,申卫红,张晴菊,等.重度烧伤患者细胞因子水平的变化及其临床意义[J].南京医科大学学报(自然科学版),2010,30(12):1778-1780.
[18] 吴孝苹,王东,段劲峰,等.抗焦虑抑郁治疗对烧伤患者血小板5-HT水平、血小板计数和细胞因子的影响[J].四川大学学报(医学版),2010,41(2):356-358.

备注/Memo

备注/Memo:
[基金项目] 武汉市卫计委2014年度武汉市临床医学科研项目(WX14B13)
更新日期/Last Update: 2018-01-05