[1]张荣鑫,王婷,陈亚会,等.0.03%他克莫司联合卡介菌多糖核酸治疗糜烂型口腔扁平苔藓临床观察[J].中国皮肤性病学杂志,2018,(01):42-44.[doi:10.13735/j.cjdv.1001-7089.201706021]
 ZHANG Rongxin,WANG Ting,CHEN Yahui,et al.Observation on Efficacy of 0.03% Tacrolimus Ointment Combined with BCG-PSN in Treatment of Patients with Erosive Oral Lichen Planus[J].The Chinese Journal of Dermatovenereology,2018,(01):42-44.[doi:10.13735/j.cjdv.1001-7089.201706021]
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0.03%他克莫司联合卡介菌多糖核酸治疗糜烂型口腔扁平苔藓临床观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年01期
页码:
42-44
栏目:
临床经验
出版日期:
2018-01-01

文章信息/Info

Title:
Observation on Efficacy of 0.03% Tacrolimus Ointment Combined with BCG-PSN in Treatment of Patients with Erosive Oral Lichen Planus
作者:
张荣鑫1王婷1陈亚会1柴松岭2
1.大连医科大学附属第二医院,辽宁 大连 116027; 2.大连医科大学口腔医学院,辽宁 大连 116044
Author(s):
ZHANG Rongxin1 WANG Ting1 CHEN Yahui1CHAI Songling 2
1.The Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China; 2.Stomatology College of Dalian Medical University, Dalian 116044, China
关键词:
0.03%他克莫司软膏 卡介菌多糖核酸 扁平苔藓口腔糜烂型
Keywords:
0.03% Tacrolimus ointment BCG polysaecharide and nucleis acid(BCG-PSN) Lichen planus oral erosive
分类号:
R 781.5+9
DOI:
10.13735/j.cjdv.1001-7089.201706021
文献标志码:
B
摘要:
目的 观察局部应用0.03%他克莫司软膏联合卡介菌多糖核酸治疗糜烂型口腔扁平苔藓的疗效。方法 将入选的46例糜烂型口腔扁平苔藓患者随机分成治疗组和对照组,治疗组(23例)给予皮损局部外涂0.03%他克莫司软膏(2次/d,早晚餐后),联合卡介菌多糖核酸注射液2mL,肌肉注射隔日1次; 对照组(23例)予单纯外涂0.03%他克莫司软膏,两组均治疗8周判定疗效,治疗结束后观察糜烂面积,采用直观类比标尺法记录疼痛程度,进行疗效评估。结果 治疗组的有效率和显效率(86.96%,52.17%)显著高于对照组(59.09%,22.73%),差异具有统计学意义(P<0.05)。治疗过程中,两组均出现轻微不良反应,均可耐受,未影响疗程。停药后6个月,治疗组复发率为25.00%,对照组复发率为40.00%,差异无统计学意义(P>0.05)。结论 0.03%他克莫司软膏联合卡介菌多糖核酸治疗糜烂型口腔扁平苔藓疗效优于单纯外用0.03%他克莫司软膏,且复发率低。
Abstract:
Objective To observe the efficacy of 0.03% tacrolimus ointment combined with BCG-PSN in treatment of patients with erosive oral lichen planus.Methods Forty-six patients with erosive oral lichen planus were randomly divided into two groups: treatment group(23 cases)and control group(23 cases).The treatment group were given 0.03% tacrolimus ointment(bid),and BCG-PSN(2mL, qod)injection as well; the control group were only given 0.03% tacrolimus ointment.After the eight-week-long treatment, the erosion area shall be observed, and the visual analogue scale method was used to record the degree of pain.Results After 8 weeks treatment, the total effective rate and excellence rate of the treatment group(86.96%,52.17%)were significantly higher than that of the control group(59.09%,22.73%)(P<0.05).Neither of the group had severe adverse effect, which had not affected the process of treatment.Followup showed that the recurrence rate in the treatment group(25.00%)was lower than that in the control group(40.00%), there is no significant statistical difference between them(P>0.05).Conclusion The effect of 0.03% tacrolimus ointment combined with BCG-PSN was better than that of the simplex 0.03% Tacrolimus Ointment, and in addition, the recurrence rate was low.

参考文献/References:

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备注/Memo

备注/Memo:
[通讯作者] 柴松岭,E-mail:chaisongling@hotmail.com
更新日期/Last Update: 2018-01-05