[1]揭丽云,李强,董海玲,等.梅毒血清试验呈前带现象的恶性梅毒1例[J].中国皮肤性病学杂志,2017,(06):647-649.[doi:10.13735/j.cjdv.1001-7089.201611105]
 JIE Li yun,LI Qiang,DONG Hai ling,et al.A Case of Malignant Syphilis with Syphilis Prezone Phenomenon[J].The Chinese Journal of Dermatovenereology,2017,(06):647-649.[doi:10.13735/j.cjdv.1001-7089.201611105]
点击复制

梅毒血清试验呈前带现象的恶性梅毒1例
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2017年06期
页码:
647-649
栏目:
性传播疾病
出版日期:
2017-06-01

文章信息/Info

Title:
A Case of Malignant Syphilis with Syphilis Prezone Phenomenon
作者:
揭丽云1李强2董海玲2王清玉2刘玮2
1遵义医学院,贵州 遵义 563000;2中国人民解放军空军总医院皮肤科,北京 100142
Author(s):
JIE Liyun1LI Qiang2DONG Hailing2WANG Qingyu2LIU Wei2
1Zunyi Medical College,Zunyi 563000,China ;2Department of Dermatology,General Hospital of the Air Force PLA, Beijing 100142,China
关键词:
二期梅毒恶性前带现象
Keywords:
Secondary syphilis Malignant Syphilis prezone phenomenon
分类号:
R 759.1
DOI:
10.13735/j.cjdv.1001-7089.201611105
文献标志码:
B
摘要:
患者男,42岁。全身反复红斑丘疹并溃疡,进行性加重2个月。头面、躯干、四肢及阴茎可见较多红色丘疹、结节、斑肿块、浅表溃疡,部分皮损表面覆有黑色蛎壳样痂皮。右腰部皮损组织病理示:真皮上部大量炎细胞浸润,以淋巴细胞、浆细胞、嗜中性粒细胞为主;免疫组织化学示:CD138(+),Ki67(+<30%),TCR重排阴性。TPPA阳性,RPR 1∶2,1∶4,1∶8,1∶16均阴性,1∶64,1∶128阳性。诊断:梅毒血清试验呈前带现象(syphilis prezone phenomenon)的恶性梅毒。
Abstract:
A 42yearold male presented with erythema papules, and skin ulceration on the entire body for 2 months progressively Dermatological examination showed a number of red papules, plaques, nodules and superficial ulcers in head and face,arms and legs and the penis, some of the lesions were covered with black rupia like crusts The histopatologic examination showed dermis with a large number of infiltrating inflammation cells, mainly lymphocytes, plasma cells and neutrophils Immunohistochemistry results demonstrated CD138 were positive and Ki67(+<30%) TCR gene rearrangement test were negative Serologic test for syphilis,TPPA antibody were positive, and RPR test 1∶2,1∶4,1∶8,1∶16 were both negative, however, 1∶64,1∶128 were positiveThe diagnosis of secondary syphilis(malignant syphilis with syphilis prezone phenomenon)w〖KG-*4〗as made

参考文献/References:

[1] Wan C, Su XH. Diagnosis and treatment of malignant syphilis[J]. J Clin Dematol, 2015,44(3):193-195. 
[2] Bayramgííeler D, Bilen N, Yildiz K, et al. Lues maligna in a chronic alcoholic patient[J]. J Dermatol, 2005,32(3):217-219. 
[3] Cripps DJ, Curtis AC. Syphilis maligna praecox.Syphilis of the great epidemic?An historical review[J]. Arch Intern Med, 1967,119(4):411-418. 
[4] 万川, 苏晓红. 恶性梅毒的诊断和治疗[J].临床皮肤科杂志,2015,44(3):193-194. 
[5] Weis L, Bonamigo RR, Weber MB, et al. Malignant syphilis and neurolues in an HIV infected patient[J]. Int J Dermatol, 2010,49(5):590-592. 
[6] Witkowski JA, Parish LC. The great imitator:malignant syphilis with hepatitis[J]. Clin Dermatol, 2002,20(2):156-163. 
[7] Wang H, Wang X, Li S. A case of lues maligna in an AIDS patient[J]. Int J STD AIDS, 2012,23(8):599-600. 
[8] 王红兰, 游晓意, 庄永灿. 梅毒并发HIV 感染2 例[J].中国皮肤性病学杂志,2016,30(10):1037-1038. 
[9] Amico R, Zalusky R. A case of lues maligna in a patient with acquired immunodeficiency syndrome AIDSP[J]. Scand J Infect Dis, 2005,37(9):697-700. 
[10] Bertand J, Labrecque LG, Belisle A. Lues maligna and Bell’s palsy :report of a case in a immunocompetent host[J].Int J Dermatol, 2012,103(5):437-439. 
[11] de Unamuno Bustos B, Ballester SR, Sánchez GJ, et al. Malignant syphilis with ocular involvement in an immunocompetent patient[J]. Int J Dermatol, 2013,53(1):1-3. 
[12] 祝贺, 杨蓉娅. 恶性梅毒带来的提示[J].实用皮肤病学杂志,2014,7(5):400.
[13] Watson KM, White JM, Salisbury JR, et al. Lues maligna[J]. Clin Exp Dermatol, 2004,29(6):625-627. 
[14] Lin R. Detection and analysis o f 56 patients with syphilis prezone phenomenon[J]. Chinese Community Doctors, 2015,31(25):116-118. 
[15] 唐旭华, 周晖, 何定阳, 等. 蛎壳状二期梅毒疹1 例[J].皮肤性病诊疗学杂志,2016,23(1):38-39.
[16] GarcíaMartínez FJ, FemándezRedondo V, SánchezAguilar D, et al. Malignant syphilis in an immunocompetent patient[J]. Actas Demosfiliogr, 2012,103(5):437-439. 
[17] Cid PM, Cuds ES, Zamora VFX, et al. Pathologically confirmed 〖JP3〗malignant syphilis using immunohistochenmical staining :report of 3 cases and review of the literature[J]. Sex Transm Dis, 2014,41(12):94-97. 〖JP〗
[18] Li JH, Guo H, Gao XH, et al. Mutiple skin ulcers from malignant syphilis[J]. Lancet, 2015,386(10003):1564.

相似文献/References:

[1]周优优,高明阳.砷致HaCaT恶性转化细胞热休克蛋白27水平变化的观察[J].中国皮肤性病学杂志,2015,(02):122.[doi:10.13735/j.cjdv.1001-7089.201407076]
 ZHOU You you,GAO Ming yang.The Change of HSP27 in HaCaT Malignant Transformation Cell Induced by Arsenic[J].The Chinese Journal of Dermatovenereology,2015,(06):122.[doi:10.13735/j.cjdv.1001-7089.201407076]
[2]郭姗姗,曹碧兰,熊琦,等.表现为脱发并多种皮疹的二期梅毒1例[J].中国皮肤性病学杂志,2015,(02):164.[doi:10.13735/j.cjdv.1001-7089.201406141]
 GUO Shan shan,CAO Bi lan,XIONG Qi,et al.A Case of Secondary Syphilis with Alopecia,Multiform Rashes[J].The Chinese Journal of Dermatovenereology,2015,(06):164.[doi:10.13735/j.cjdv.1001-7089.201406141]
[3]王红枫,干慧慧,梅莉红,等.银屑病样二期梅毒1例[J].中国皮肤性病学杂志,2015,(02):169.[doi:10.13735/j.cjdv.1001-7089.201407043]
 WANG Hong feng,GAN Hui hui,MEI Li hong,et al.A Case of Secondary Syphilis with Psoriasiform rash[J].The Chinese Journal of Dermatovenereology,2015,(06):169.[doi:10.13735/j.cjdv.1001-7089.201407043]
[4]姚学群,唐勇.泛发性结节性二期梅毒1例[J].中国皮肤性病学杂志,2015,(05):495.[doi:10.13735/j.cjdv.1001-7089.201412030]
 YAO Xue qun,TANG Yong.A Case of Generalized Nodular Secondary Syphilis[J].The Chinese Journal of Dermatovenereology,2015,(06):495.[doi:10.13735/j.cjdv.1001-7089.201412030]
[5]滕蔚,金艳,史同新.儿童获得性梅毒20例临床分析[J].中国皮肤性病学杂志,2015,(08):825.[doi:10.13735/j.cjdv.1001-7089.201401081]
 TENG Wei,JIN Yan,SHI Tong xin.Clinical Analysis of 20 Cases of Acquired Syphilis in Children[J].The Chinese Journal of Dermatovenereology,2015,(06):825.[doi:10.13735/j.cjdv.1001-7089.201401081]
[6]罗斌华,杨桂兰,杜华.恶性黑棘皮病、大疱性类天疱疮并食管癌1例[J].中国皮肤性病学杂志,2015,(09):950.[doi:10.13735/j.cjdv.1001-7089.201410067]
 LUO Bin hua,YANG Gui lan,DU Hua.A Case of Malignant Acanthosis Nigricans Accompanied with Esophageal Carcinoma and Bullous Pemphigoid[J].The Chinese Journal of Dermatovenereology,2015,(06):950.[doi:10.13735/j.cjdv.1001-7089.201410067]
[7]吴丹,王涛,刘跃华,等.播散性环状红斑表现的二期梅毒疹1例[J].中国皮肤性病学杂志,2016,(01):56.[doi:10.13735/j.cjdv.1001-7089.201502094]
 WU Dan,WANG Tao,LIU Yue hua,et al.A Case of Disseminated Annular Erythemalike Secondary Syphilis[J].The Chinese Journal of Dermatovenereology,2016,(06):56.[doi:10.13735/j.cjdv.1001-7089.201502094]
[8]曾磊,姚磊,付黎影,等.类似银屑病样皮损的二期梅毒 1 例[J].中国皮肤性病学杂志,2016,(06):596.[doi:10.13735/j.cjdv.1001-7089.201501126]
 ZENG Lei,YAO Lei,FU Li-ying,et al.A Case of Secondary Syphilis Mimicking Psoriasis[J].The Chinese Journal of Dermatovenereology,2016,(06):596.[doi:10.13735/j.cjdv.1001-7089.201501126]
[9]闫红梅,王树村,黄霞.二期梅毒误诊1例[J].中国皮肤性病学杂志,2016,(12):1301.[doi:10.13735/j.cjdv.1001-7089.201509102]
 YAN Hong-mei,WANG Shu-cun,HUANG Xia.A Case of Misdiagnosed Secondary Syphilis[J].The Chinese Journal of Dermatovenereology,2016,(06):1301.[doi:10.13735/j.cjdv.1001-7089.201509102]
[10]付锐,杨钧.二期梅毒误诊为银屑病2例[J].中国皮肤性病学杂志,2017,(01):104.[doi:10.13735/j.cjdv.1001-7089.201604051]
 FU Rui,YANG Jun.Two Cases of Secondary Syphilis Misdiagnosed as Psorias[J].The Chinese Journal of Dermatovenereology,2017,(06):104.[doi:10.13735/j.cjdv.1001-7089.201604051]

备注/Memo

备注/Memo:
[通讯作者]刘玮,E-mail:lwei5811@126com
更新日期/Last Update: 2017-06-05