[1]邵丽丽,郭媛丽,刘全忠.自噬在沙眼衣原体持续感染中的可能作用[J].中国皮肤性病学杂志,2016,(12):1287-1289.[doi:10.13735/j.cjdv.1001-7089.201601058]
 SHAO Li-li,GUO Yuan-li,LIU Quan-zhong.Possible Role of Autophagy in Persistent Infection with Chlamydia Trachomatis[J].The Chinese Journal of Dermatovenereology,2016,(12):1287-1289.[doi:10.13735/j.cjdv.1001-7089.201601058]
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自噬在沙眼衣原体持续感染中的可能作用
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2016年12期
页码:
1287-1289
栏目:
综述
出版日期:
2016-12-20

文章信息/Info

Title:
Possible Role of Autophagy in Persistent Infection with Chlamydia Trachomatis
作者:
邵丽丽郭媛丽刘全忠
[作者单位] 天津医科大学总医院皮肤性病科/皮肤性病研究所,天津300052
Author(s):
SHAO Li-liGUO Yuan-li LIU Quan-zhong
Department of Dermatology, General Hospital of Tianjin Medical University, Tianjin 300052, China
关键词:
沙眼衣原体 自噬 持续感染
Keywords:
Chlamydia trachomatis Autophagy Persistent infection
分类号:
R 374
DOI:
10.13735/j.cjdv.1001-7089.201601058
文献标志码:
B
摘要:
沙眼衣原体的持续感染是现阶段临床最难解决的问题,可以引起如沙眼性失明、输卵管 性不孕和长期的上生殖道感染等。抗生素难以清除部分患者体内的沙眼衣原体。另一个难以解 释的问题是沙眼衣原体为什么能在人体长期存在?沙眼衣原体感染难以激发人体的有效免疫、那 么自噬机制能在衣原体持续感染中起到什么作用?近几年来,随着对沙眼衣原体感染与自噬机制 的关系研究逐渐增多,对于沙眼衣原体通过抑制宿主细胞的自噬机制而自身繁殖以及通过增强自 噬机制加强胞内清除沙眼衣原体有了一定的认识,本文就此作一综述。
Abstract:
Persistent infection with Chlamydia trachomatis is the most challenging issue in clinic.It can cause blindness, tubal infertility and long-term upper genital tract infection.It is difficult for antibiotics to eliminate Chlamydia trachomatis from some patients.It is also difficult to explain why Chlamydia trachomatis can survive in humans for long-term.Chlamydia trachomatis infection cannot easily induce effective immune responses, and then what is the role of autophagy mechanism in the persistent chlamydial infection? Recently, with the increasing research in the association of Chlamydia trachomatis infection and autophagy mechanism, it becomes aware that Chlamydia trachomatis reproduce via inhibition of autophagy in the host cell and that intracellular Chlamydia trachomatis can be eliminated through enhancing autophagy.This aspect is reviewed here.

参考文献/References:

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金面上项目(31370211) [通讯作者] 刘全忠,E-mail:liuquanzhong@medmail.com.cn
更新日期/Last Update: 2016-12-20