[1]陈秀芳,周燕华,刘栋华,等.两性霉素B联合曲酸作用于马尔尼菲青霉的体外药敏实验[J].中国皮肤性病学杂志,2015,(11):1123-1126.[doi:10.13735/j.cjdv.1001-7089.201505043]
　CHEN Xiu fang,ZHOU Yan hua,LIU Dong hua,et al.Combination Antimicrobial Susceptibility Tests for Amphotericin B with Kojic Acid Against Penicilliun Marneffei[J].The Chinese Journal of Dermatovenereology,2015,(11):1123-1126.[doi:10.13735/j.cjdv.1001-7089.201505043]
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两性霉素B联合曲酸作用于马尔尼菲青霉的体外药敏实验
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2015年11期
页码:
1123-1126
栏目:
论著
出版日期:
2015-11-01

文章信息/Info

Title:
Combination Antimicrobial Susceptibility Tests for Amphotericin B with Kojic Acid Against Penicilliun Marneffei
作者:
陈秀芳; 周燕华; 刘栋华; 郑冬燕
广西医科大学第一附属医院皮肤性病科，广西 南宁 530021
Author(s):
CHEN Xiu fang; ZHOU Yan hua; LIU Dong hua; ZHENG Dong yan
Department of Dermatology/Venerology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China
关键词:
马尔尼菲青霉; 曲酸; 两性霉素B; 联合药敏
Keywords:
Penicilliun marneffei; Kojic acid; Amphotericin B; Combination antimicrobial susceptibility
分类号:
R 379
DOI:
10.13735/j.cjdv.1001-7089.201505043
文献标志码:
A
摘要:
目的 研究曲酸和两性霉素B在体外联合抵抗马尔尼菲青霉中的相互作用。方法 参照美国国家临床实验标准化委员会（NCCLS）提出的标准（M27A2方案），采用棋盘微量稀释法对马尔尼菲青霉10株临床分离株和8株野生竹鼠分离株的酵母相进行曲酸和两性霉素B的体外联合药敏试验。结果 曲酸和两性霉素B联合应用，两种药物对抗17株马尔尼菲青霉的联合药敏050
Abstract:
Objective In order to investigate the antifungal interaction between amphotericin B and kojic acid against Penicilliun marneffei in vitroMethods According to M27A2 method of NCCLS,combination antimicrobial susceptibility tests for kojic acid with amphotericin B against yeast phase of Pmarneffei,10 clinical isolates and 8 bamboo rat isolates,were assayed by the checkerboard microdilution methodResults Combination antimicrobial susceptibility tests for amphotericin B with kojic acid,the fractional inhibitory concentration index (FICI) of the two agents against 17 isolates of Pmarneffei varied from 050 to 400,while the FICI was less than 050 in one isolateThe geometric mean of MIC value was 175 μg/mL when AMB against Pmarneffei isolates in aloneHowever,the geometric mean of MIC value was 082 μg/mL when AMB combined kojic acid against Pmarneffei isolates,significantly reduced in comparison with AMB alone (P<001)Conclusion Kojic acid,as a chemosensitizer,can enhance antifungal drug susceptibility of amphotericin B against yeast phase of Pmarneffei

参考文献/References:

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备注/Memo

备注/Memo:
［基金项目］〖HTSS〗 国家自然科学基金（81360238）
更新日期/Last Update: 2015-11-20